Laparoscopic, Partial Nephrectomy, Pentafecta, Renal Tumors
Conditions
Brief summary
This study aimed to identify predictive factors associated with the achievement of pentafecta outcomes following partial nephrectomy.
Detailed description
Partial nephrectomy (PN) is widely considered the preferred treatment for clinical T1 (cT1) renal masses, primarily because it preserves kidney function more effectively than radical nephrectomy. The trifecta metric includes three components: warm ischemia time (WIT) of ≤ 25 minutes or cold ischemia time (CIT) of ≤ 60 minutes, negative surgical margins, and the absence of perioperative major complications. The pentafecta expands upon these criteria by adding two additional parameters: preservation of ≥ 90% of the estimated glomerular filtration rate (eGFR) and no progression in chronic kidney disease (CKD) stage within 12 months postoperatively.
Interventions
PROCEDUREOpen Partial Nephrectomy
Patients underwent open partial nephrectomy.
PROCEDURELaparoscopic Partial Nephrectomy
Patients underwent laparoscopic partial nephrectomy.
Sponsors
South Valley University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years. * Both sexes. * Patients who diagnosed with clinical T1 or T2a N0M0 renal tumors who were suitable candidates for partial nephrectomy
Exclusion criteria
* Severe and irreversible coagulopathy. * Anatomically unfavorable tumor location. * Extensive encasement of the renal pedicle. * Diffuse invasion of the renal vein or central collecting system. * Adjacent organ invasion consistent with stage cT4 disease. * Regional lymphadenopathy (stage cTxN1), or anticipated retention of less than 20% of total nephron mass.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predictor of pentafecta achievement | 12 months postoperatively | Predictor of pentafecta achievement, such as smoking index, was recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Surgery duration | Intraoperatively | Surgery duration was recorded. |
| Length of hospital stay | Till discharge from hospital (Up to one week). | Length of hospital stay was recorded from admission till the discharge from hospital. |
| Intraoperative complications | Intraoperatively | Intraoperative complications were recorded. |
| Amount of blood loss | Intraoperatively | Amount of blood loss was recorded. |
| Analgesic requirements | 24 hours postoperatively | Incidence of required analgesic was recorded. |
| Incidence of complications following surgery | 12 months postoperatively | Incidence of complications following surgery were recorded. |
| Degree of pain | 24 hours postoperatively | Each patient will be instructed about postoperative pain assessment with the visual analog scale (VAS). VAS (0 represents no pain while 10 represents the worst pain imaginable). |
Countries
Egypt
Outcome results
None listed