The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Analysis of the Relationship Between the Concentration of the Brain Derived Neurotrophic Factor (BDNF) in Plasma, the Occurrence of BDNF Gene Polymorphism (Val66Met) and White Blood Cell Markers and the Incidence of Postoperative Central Nervous System Disorders in Patients Undergoing General Anesthesia for Cardiac Surgery With Extracorporeal Circulation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06967779

Enrollment

107

Registered

2025-05-13

Start date

2021-07-01

Completion date

2024-07-01

Last updated

2025-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

BDNF, CABG, Delirium - Postoperative

Brief summary

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

include: 1. Age \> 18 years. 2. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB). 3. Ability to understand and sign an informed consent form.

Exclusion criteria

include: 1. Emergency surgery. 2. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score \<15. 3. Baseline delirium (positive CAM test prior to surgery). 4. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia. 5. Inability to understand Polish language. 6. Inability to give and sign informed consent due to auditory or visual dysfunction.

Design outcomes

Primary

Measure	Time frame
The main aim of the study will be to assess the correlation between brain function disorders, defined as abnormal BDNF levels, and postoperative delirium.	Up to a year after the procedure.

Countries

Poland

Outcome results