Acute Heart Failure Syndrome
Conditions
Keywords
acute heart failure, respiratory virus
Brief summary
Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort. The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.
Interventions
None listed
Sponsors
Minjae Yoon
Samsung Medical Center
Seoul St. Mary's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Inclusion criteria
* Adult aged 19 years or older admitted to the cardiology department with acute heart failure * NT-proBNP \>300 pg/mL * Clinician judgement of possible respiratory viral infection (fever \>38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP \>5 mg/dL) * Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons
Exclusion criteria
* Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP \>180mmHg or DBP \>110mmHg), haemoglobin \<7g/dL or AHF precipitated by medication non-adherence) * If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD * If there is a clear other source of infection that can explain the fever
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory virus PCR detection rate | Within 3 days of admission | Respiratory virus PCR detection rate (especially RSV, influenza virus) in acute HF |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Days of hospitalization | From admission to discharge during index hospitalization (upto 30 days) | Days of hospitalization |
| Rate of ICU care or ventilation | From admission to discharge during index hospitalization (upto 30 days) | Rate of ICU care or ventilation |
| In hospital mortality | From admission to discharge during index hospitalization (upto 30 days) | In hospital mortality |
| mortality | 12 month | after discharge, 12-month mortality |
| Rehospitalization | 12month | after discharge, 12-month rehospitalization |
Countries
South Korea
Contacts
CONTACTMinjae Yoon, MD
Outcome results
None listed