ARDS (Moderate or Severe)
Conditions
Brief summary
Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
Detailed description
Collecting Medical Records, Demographic Characteristics, and Clinical Data of Moderate to Severe ARDS Patients Requiring Prone Positioning Treatment at Chengdu Pixdu District People's Hospital, Sichuan Provincial People's Hospital, The Fourth People's Hospital of Chengdu, and Chengdu Shuangliu District First People's Hospital from March 2025 to March 2026.
Interventions
BEHAVIORALProne ventilation
Cerebral Blood Flow Monitoring Before and After Prone Ventilation in Patients with ARDS.Cerebral blood flow,intracranial pressure,and systemic hemodynamic monitoring were performed at the following time points:before prone positioning(T0),1 hour after prone ventilation(T1),12 hours after prone ventilation(T2),1 hour after returning to the supine position(T3),and 7 days after returning to the supine position(T4).
Sponsors
Sichuan Provincial People's Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age≥18 years * Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation * Expected duration of mechanical ventilation\>48 hours * Written informed consent obtained
Exclusion criteria
* Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension) * Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics * Life-threatening ARDS * Patients who are unable to undergo neurological assessment * Poor image quality or absence of images
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuroimaging Studies | From enrollment to 2 weeks after the end of treatment. | Cranial CT or MRI Scans Conducted Before and After Prone Positioning to Detect New-Onset Neurological Complications Such as Cerebral Edema, Intracranial Hemorrhage, and Cerebral Infarction |
| Biomarker Detection | From enrollment to 2 weeks after the end of treatment. | Blood samples were collected for NSE(Neuron-specific Enolase)and IL-6(Interleukin-6)before and after prone positioning. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence rate of delirium | From enrollment to 2 weeks after the end of treatment. | Assessment using the Confusion Assessment Method for the Intensive Care Unit(CAM-ICU)was conducted before and after prone position therapy in patients. |
| Cognitive function | From enrollment to 2 weeks after the end of treatment. | Assessment using the Mini-Mental State Examination(MMSE)was conducted before and after prone position therapy in patients. |
Countries
China
Contacts
Primary Contactlingai Pan, PhD
Outcome results
None listed