Disease Related Malnutrition, Geriatric Assessment, High Systemic Inflammation
Conditions
Brief summary
The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .
Interventions
OTHERSingle leg training
All subjects will train one leg twice daily.
Sponsors
Bispebjerg Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hospitalised at the geriatric department at Bispebjerg Hospital with an expected admission time of minimum 7 days * Have Disease Related Malnutrition (DRM) * Able to carry out strength training * Able to understand the study information, as assessed by the research team
Exclusion criteria
* Current use of anti-inflammatory medication * Liver failure * Short bowel syndrome * Chrohn's or colitis * Terminally ill
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FSR in high vs. low inflammation group | 7 days (or until hospital discharge) | The primary outcome is the muscle protein fractional synthesis rate (FSR) in the high inflammation group vs. the low inflammation group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle size between groups | 7 days (or until hospital discharge) | Change in muscle size during the study period between the three groups |
| FSR in trained vs. non trained leg | 7 days (or until hospital discharge) | Effect of training on the muscle protein fractional synthesis rate |
| Inflammation in regular vs. antiinflammatory diet | 7 days (or until hospital discharge) | Comparison of the changes in plasma C-Reactive Protein (CRP) from day 1 till discharge between the group ingesting regular diet vs. the group ingesting an anti-inflammatory diet. |
| Muscle size in trained vs. untrained leg | 7 days (or until hospital discharge) | The difference in muscle size in trained vs. untrained leg measured using ultrasound |
| Change in muscle strength between groups | 7 days (or until discharge) | Description: Change in muscle strength during the study period between the three groups. Hand muscle strength is measured using a hand dynamometer, and leg muscle strength (MVC) is measured using an isokinetic dynamometer. Time Frame: 7 days (or until hospital discharge) |
| Muscle strength in trained vs. untrained leg | 7 days (or until hospital discharge) | The difference in leg muscle strength (MVC) in trained vs. untrained leg measured using an isokinetic dynamometer. |
| AA uptake following feeding | 7 days (or until hospital discharge) | Plasma amino acid profile following a standard meal |
Other
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of training | 7 days (or until hospital discharge) | It will be reported if the subjects can complete a minium of 80% of the twice-daily training sessions. |
Countries
Denmark
Outcome results
None listed