Acute Respiratory Distress Syndrome (ARDS), Ventilator-induced Lung Injury
Conditions
Brief summary
This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung injury, the investigators intend to establish a prognostic model that reveals lung injury and heterogeneity, enabling risk stratification and guiding individualized treatment.
Interventions
OTHERNot applicable- observational study
Not applicable- observational study
Sponsors
XiaoJing Zou,MD
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Meet the new 2023 ARDS global definition; 2. Age 18-80 years
Exclusion criteria
1. Expected death within 24 hours of screening; 2. Metastatic cancer (active malignancy with distant metastases); 3. Severe psychiatric disorders; 4. Pregnancy or postpartum status; 5. Pneumothorax or moderate to large pleural effusion without adequate drainage; 6. Chronic respiratory failure; 7. Patients with pulmonary embolism or pulmonary hypertension; 8. Heart failure patients: EF \<50% or NYHA class III or IV; 9. Patient/family refusal to participate; 10. Participation in another interventional trial within 3 months prior to enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality rate | From date of study enrollment (Day 0) until Day 28 |
Secondary
| Measure | Time frame |
|---|---|
| 60-day all-cause mortality rate | 60 days post-enrollment |
| 90-day all-cause mortality rate | 90 days post-enrollment |
| Duration of mechanical ventilation (days) | From intubation to successful extubation, up to 28 days |
| ICU mortality rate | From ICU admission to discharge, up to 24 weeks |
| ICU length of stay (days) | From ICU admission to discharge, up to 24 weeks |
| Hospital length of stay | From hospital admission to discharge, up to 24 weeks |
| Ventilator-free days (VFDs) at 28 days | 28 days post-enrollment |
Countries
China
Contacts
Primary ContactXiaojing Zou Zou
Outcome results
None listed