Burn Injury, Hyperthermia
Conditions
Keywords
Burn Survivor, Burn, humid, dry, core temperature, heat, body temperature
Brief summary
The purpose of this project is to identify the effects of a severe burn injuries in humans on core temperature responses during work:rest cycles while in a heated environment.
Detailed description
Non-burned control participants and participants who experienced serious burns covering ≥20% of their body surface area will be investigated. Participants will undergo up to three work:rest cycles in the heat (via our environmental chamber) set to no higher than 40 °C. The work:rest cycle will comprise of 30 min of exercise that is followed by up to 20 min of rest, while staying in the heated conditions. Three consecutive work:rest cycles will be performed as illustrated in the protocol document. During one visit, this protocol will be performed in a low humidity state. During the other visit (randomized and crossover), this protocol will be performed in a high humidity state.
Interventions
None listed
Sponsors
University of Texas Southwestern Medical Center
Texas Health Resources
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
for Non-burned Individuals: * Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be between the ages of 18 and 65.
Exclusion criteria
for Non-burned Individuals: * Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded. Participants must not have had a serious burn injury requiring more than 1 night stay in the hospital. Inclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group): \- Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering 20-40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in core temperature | From the start of exercise to the end of the last rest period. Approximately at 0 and 170 minutes. | Change in core body temperature will be measured either from a temperature sensor pill or from a rectal thermometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Heart Rate | From the start of exercise to the end of the last rest period. Approximately at 0 and 170 minutes. | Heart rate will be measured from ECG electrodes attached to the participant. |
Countries
United States
Contacts
CONTACTCraig Crandall, PhD
CONTACTErin Harper, BS
Outcome results
None listed