Alzheimer's Disease, Brain Atrophy, Cortical and Subcortical Atrophy, Hippocampus, Leukoaraiosis, Magnetic Resonance Imaging, Neurodegenerative Diseases
Conditions
Brief summary
This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease. Researchers are focusing on the hippocampus, a part of the brain that shrinks in people with Alzheimer's. The study will also explore other brain changes that often happen alongside hippocampal shrinkage. By analyzing these brain images, the study hopes to find ways to diagnose Alzheimer's earlier and more accurately using advanced imaging techniques.
Interventions
None listed
Sponsors
Centre Hospitalier de Saint-Denis
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients who underwent a brain MRI (3D T1 Bravo and Cube FLAIR sequences) between January 2018 and June 2022. * Diagnosis of Alzheimer's disease (for the Alzheimer group). * No neurological disease for control group participants. * Complete clinical and biological assessments available. * Quality imaging without motion artifacts.
Exclusion criteria
* Incomplete clinical or radiological data. * Poor image quality (e.g., motion artifacts). * Presence of other neurodegenerative or psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hippocampal Volume Measured by 3D MRI | Retrospective analysis between January 2018 and June 2022 | Objective volumetric measurement of the right and left hippocampus using 3D T1 Bravo MRI sequences, allowing quantification of hippocampal atrophy. |
Countries
France
Outcome results
None listed