Cholelithiases
Conditions
Keywords
Cholelithiases, Cholecystectomy, Laparoscopy
Brief summary
Objective: To determine the effect of low-dose ketamine versus lignocaine on post-operative pain in patients undergoing LC under general anesthesia in a tertiary care hospital. Sample Selection: Patients of both the gender of age at least 18 years, planned for elective LC with ASA grade I-II were included. Patients with obesity, history of alcohol consumptions, drug abusers, uncontrolled hypertension and diabetics, with chronic pain, allergic to study drugs, having neurological disorders, unable to understand pain scoring system and converted to open LC were excluded.
Interventions
Ketamine group received ketamine at 0.2mg/kg bolus intravenously followed by ketamine infusion at rate of 0.2mg/kg/hr throughout the surgery.
IV Lignocaine was given at the rate of 1 mg/kg/hr.
Sponsors
Fazaia Ruth Pfau Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients of both the gender of age at least 18 years * Patients planned for elective LC * Patients with ASA grade I-II were included.
Exclusion criteria
* Patients with obesity, * Patients with history of alcohol consumptions, uncontrolled hypertension and diabetics, * Drug abusers * Patients with chronic pain * Patients allergic to study drugs * Patients having neurological disorders or unable to understand pain scoring system * Patients converted to open LC
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post operative Pain | 24 hours | Pain was assessed using Numeric Rating Scale which is a ten point scoring scale ranging from 0-10 for ranking pain where 0 means no and 10 means worst pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to rescue analgesia | 24 hours | Time to rescue analgesia was defined as time point at which patient will be given first rescue analgesia for pain of score more 5 or above. |
| Wound Closure | End of Surgery | The time between the incision and the wound's closure was used to define the length of the surgery. |
Countries
Pakistan
Outcome results
None listed