Lung Cancer
Conditions
Keywords
Magnetic Resonance Imaging, Low Dose Computed Tomography
Brief summary
Low-dose computed tomography (LDCT) is used in individuals at high risk of developing lung cancer (smokers over 50 years of age), as it allows for the identification of pulmonary nodules, which, in a small percentage of cases, may represent early-stage lung cancer. However, according to LUNG-RADS guidelines, individuals undergoing screening must repeat multiple LDCT scans, as the comparison between successive LDCT scans enables the assessment of existing nodules' progression and the identification of newly developed pulmonary nodules. This results in cumulative exposure to ionizing radiation, increasing the risk of radiation-induced cancers. This study addresses, through the implementation of new imaging techniques utilizing the latest and most advanced technological innovation (high-field 3T Magnetic Resonance Imaging (MRI) with artificial intelligence), the critical challenge of reducing radiation exposure in current LDCT-based screening programs, proposing the use of MRI as an alternative screening method to LDCT.
Interventions
PROCEDUREMagnetic Resonance Imaging
3T Magnetic Resonance Imaging
Sponsors
IRCCS San Raffaele
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
* Age ≥ 18 years * Indication to first lung cancer screening with LDCT according to international guidelines * Indication to repeated lung cancer screening with LDCT according to international guidelines
Exclusion criteria
* Age \< 18 years * contraindication to MRI * presence of metallic implants likely to hamper MRI image quality * inability to hold breath for 15-20 seconds * claustrophobia * refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the sensitivity and specificity for lung nodule detection of a Single Breath- Hold Lung non-contrast MRI scan (SBH-Lung-MRI), lasting less than 20 seconds, in comparison to LDCT | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| the sensitivity and specificity for lung nodule detection of SBH-Lung-MRI, lasting less than 20 seconds, in comparison to two of the most accurate available sequences for MRI lung nodule detection, namely: 2D-UTE and spiral 3D- UTE MRI sequences. | 3 years |
Other
| Measure | Time frame | Description |
|---|---|---|
| The health impact of implementing a radiation-free MRI-based lung cancer screening program using the SBH-Lung-MRI approach compared to conventional LDCT screening. | 3 years | The following will be used to assess this outcome measures: number of lung cancer cases detected, stage distribution at detection, lung cancer-specific mortality, and overall mortality. |
| The cost-effectiveness of implementing a radiation-free MRI-based lung cancer screening program using the SBH-Lung-MRI approach tested in specific aim 1 compared to conventional LDCT screening. | 3 years | The following will be used to assess this outcome measures: total program costs, costs per scan, and scanner operational efficiency (e.g., cost per hour of scanner use). |
Contacts
Primary ContactAntonio A Esposito, MD
Backup ContactDavide Vignale, MD
Outcome results
None listed