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PRIDE III Prison Interventions and HIV Prevention Collaboration

PRIDE III Prison Interventions and HIV Prevention Collaboration

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06962033
Acronym
PRIDE III
Enrollment
300
Registered
2025-05-08
Start date
2024-11-05
Completion date
2028-12-01
Last updated
2026-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hiv, Opioid Use

Brief summary

The primary objective of this research project is to identify barriers to scale-up of Opioid Agonist Therapy (OAT) in the justice systems (prisons and probation) in Tajikistan, Kyrgyzstan, Moldova, and Georgia, and establish a NIATx learning collaborative to scale-up OAT, and analyze scale-up utilizing latent class growth analyses in people who inject drugs (PWID).

Detailed description

Aim 1 consists of the development of NIATx learning collaboratives with prison OAT providers (addiction care specialists or primary care doctors). This aim is an implementation science aim involving the collection of OAT scale-up data from each country's national OAT database, as well as administration of survey to prison narcologists every 6 months. Aim 2 consists of the development of NIATx learning collaboratives with probation and prison officers in Kyrgyzstan, Tajikistan, Moldova, and Georgia. Investigators will collect OAT scale-up data from each member country's national OAT database, and administer a survey to probation officers every 6 months. Investigators will also observe and interview probation clients and staff using ethnographic methods.

Interventions

BEHAVIORALOpioid Agonist Therapy

Opioid Agonist Therapy (OAT) as HIV prevention

Sponsors

Yale University
Lead SponsorOTHER
National Institute on Drug Abuse (NIDA)
CollaboratorNIH

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

Aim 1: 100 (60 prison OAT providers, 15 per country) for surveys, 40 prison OAT providers, 10 per country, for NGT) Aim 2: 200 (100 probation clients, 100 prison and probation staff (officers and leadership)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Aim 1: 1. Quantitative surveys for prison OAT providers * Being 18 years or older * Being currently assigned and working as a probation OAT provider for a probation site 2. ECHO procedures Aim 2: 1. Quantitative surveys for people in probation * Being 18 years or older * Screen yes to opioid injection on the online screener questionnaire * Currently in probation 2. Quantitative surveys for probation and prison officers * Being 18 years or older * Being currently assigned and working as a probation or prison officer at a probation site 3. Focus Groups (People in probation) * Being 18 years or older * Screen yes to opioid injection criteria on the online screener * Currently in probation 4. Focus Groups (Probation and prison officers) * Being 18 years or older * Being currently assigned and working as a probation or prison officer at a probation * Has more than 3 months of field experience * Works at a probation site within 25 kilometers of an OAT site

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Number of participants receiving opioid agonist therapy (OAT)baseline up to 4 yearsNumber of patients receiving opioid agonist therapy (OAT) per OAT site.

Secondary

MeasureTime frameDescription
Adherence to NIATx protocolbaseline up to 4 yearsAdherence to NIATx protocol: using the NIATx fidelity scale, a 19-item assesment to measure adherence to the NIATx model on a 5-point scale from 1 (No evidence) to 5 (Extensive evidence).

Countries

Georgia, Kyrgyzstan, Moldova, Tajikistan, United States

Contacts

CONTACTDavid Oliveros, MPH
david.oliveros@yale.edu202-805-8118
CONTACTJin Hee Kim, MPH
jinhee.kim@yale.edu
PRINCIPAL_INVESTIGATORFrederick L Altice, MD

Yale University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 11, 2026