Thromboembolic Stroke
Conditions
Brief summary
Rupture of vulnerable carotid, vertebral, and intracranial arterial plaques results in thromboembolic stroke. Identification of these culprit lesions is an important component of post-stroke care. This study seeks to test the feasibility of NaF PET-CT to detect these plaques and alter patient care. Prior studies have shown a high degree of correlation between NaF PET+ lesions and high-risk plaque features on high resolution MRI, including mirocalcification, necrosis, and ulceration.
Interventions
DRUGNaF PET-CT
Following a non-cardiogenic thromboembolic stroke, patients will undergo NaF PET-CT imaging to identify the culprit plaque and any other vulnerable plaques at high risk for rupture
Sponsors
Atlantic Health System
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
18 years of age or older with a non-cardiogenic thromboembolic stroke in the past 14 days.
Exclusion criteria
Less than 18 years of age, any other kind of stroke, not clinically stable to undergo PET-CT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Culprit lesion | Within 14 days of the stroke | Can NaF PET-CT within 14 days of a non-cardiogenic thromboembolic stroke identify the likely culprit plaque as a source of the stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recurrent stroke | Within 1 year of imaging | Can NaF PET-CT within 14 days of a non-cardiogenic thromboembolic stroke predict the location of a future non-cardiogenic thromboembolic stroke |
| Management change | Within 1 year of imaging | Can NaF PET-CT within 14 days of a non-cardiogenic thromboembolic stroke alter patient management |
Countries
United States
Outcome results
None listed