The Accuracy of Ultrasonic Viscoelastic Imaging in Evaluating the Severity of Chronic Kidney Diseases

A Prospective, Single-Center Study: Evaluation of Chronic Kidney Disease Severity Using Ultrasonic Viscoelastic Parameters Combined With Clinical Indicators-With Histopathological Results as Gold Standard

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06961162

Enrollment

Registered

2025-05-07

Start date

2023-10-24

Completion date

2024-06-03

Last updated

2025-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease(CKD)

Keywords

chronic kidney disease, sonoelastogrphy, fibrosis, inflammation

Brief summary

The goal of this observational study is to learn about the role of ultrasonic viscoelastic parameters in the assessing the severity of chronic kidney disease. The main question it aims to answer is: The accuracy of ultrasonic viscoelastic parameters in evaluating the degree of renal fibrosis and inflammation.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* (1) fulfilled the diagnostic criteria for CKD (disease course \> 3months); (2) underwent renal biopsy, (3) a prior 2D-SWE evaluation preceding the renal biopsy, and (4) obtained informed written consent.

Exclusion criteria

* (1) the presence of multiple renal cysts, calculi, hydronephrosis, or masses that could potentially interfere with the analysis conducted through 2D-SWE: (2) unsuccessful 2D-SWE measurements ;(3) biopsy specimens deemed inadequate due to insufficient length (less than 10 mm) or fewer than 10 glomeruli, and (4) incomplete clinical data.

Design outcomes

Primary

Measure	Time frame
renal fibrosis degree	one week

Countries

China

Outcome results