Epilepsy, Generalized, Epilepsy With Partial Onset Seizures With or Without Secondary Generalization, Psychoses
Conditions
Keywords
psychoses of epilepsy, postictal psychosis, interictal psychosis, epilepsy, clinical research
Brief summary
Background : Psychiatric comorbidities are common in epilepsy, affecting 50 to 70% of patients, especially when the epilepsy is focal and drug-resistant. Among these comorbidities, psychotic disorders (involving hallucinations and delusions) affect 8% of patients - that is, eight times more frequently than in the general population. Currently, the links between epilepsy and psychotic disorders are poorly understood and often overlooked by physicians, which impacts the mental health care of patients with epilepsy and leads to underdiagnosis. The aim of this research is to determine whether there are differences in epileptic symptoms between patients with a psychotic comorbidity and those without. Study design : The main objective of this research is to better understand whether certain emotional epileptic symptoms are associated with a higher risk of developing psychotic symptoms. The secondary objectives of this study are to investigate whether the level of consciousness during seizures is associated with a higher risk of developing psychotic symptoms. To meet these objectives, the study will include patients who (1) have epilepsy, (2) were hospitalized in the video-EEG unit of the Neurology Department at Central Hospital for seizure recording, and (3) underwent a psychiatric evaluation in the context of epilepsy between January 1, 2016, and April 1, 2025. The study will take place at the University Hospital Center (CHRU) of Nancy, in the Neurology Department, within the video-EEG unit led by Professor Louis Maillard. The research will involve comparing epileptic symptoms between the group of patients without psychosis and the group of patients with psychosis. Data collection will cover the five days of video-EEG hospitalization, along with information from the psychiatric evaluation, for a total duration of approximately one week per year. Information for participants: As part of the routine medical care, data is collected in medical records to ensure appropriate follow-up. For the purposes of this research, data from the medical record will be collected. No identifying information (such as name, initials, full date of birth, address, or social security number) will be collected. No additional visits or examinations will be required. Patients will not be contacted or asked to provide any new information.
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a confirmed diagnosis of epilepsy * Patients hospitalized for at least 5 days for a video-EEG recording * Patients with a psychiatric evaluation, conducted between 01/01/2016 and 04/01/2025. * Adult patients able to express their opposition to the use of their data.
Exclusion criteria
* Absence of seizure recorded during the video-EEG
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ictal emotions | From april 2025 to may 2025 | Clinician-assessment of ictal affective symptomatology (facial, verbal, and motor expression), based on a the visualization of an usual seizure recorded in video-EEG. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ictal consciousness | From april 2025 to may 2025 | Clinician-rating of the Consciousness Seizure Scale (CSS) validated for the assessment of level of consciousness during a seizure. Scores on the CSS range from 0 to 9, which can be interpreted as follows * 0 or 1 meaning a profound alteration of consciousness during seizure * 2 to 5 meaning an intermediate alteration of consciousness during seizure * 6 and more meaning a relatively preserved consciousness during seizure |
| Ictal dysautonomy | From april 2025 to may 2025 | Measures of neurovegetatives signs during seizures based on ictal EKG, nurse examination (palor, ...) |
| Type of aura | From april 2025 to may 2025 | Assessment of the type of aura based on the patients description of their seizure and on the video-EEG recording at the beginning of the seizure |
Countries
France
Outcome results
None listed