The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK)

The Effect of Topical Rho-kinase (ROCK) Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06960629

Enrollment

Registered

2025-05-07

Start date

2025-05-12

Completion date

2026-05-01

Last updated

2026-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pseudophakic Bullous Keratopathy, Glaucoma

Keywords

Glaucoma, Topical ROCK inhibitors, Netarsudil/latanoprost, corneal edema, pseudophakic bullous keratopathy (PBK)

Brief summary

The goal of this clinical trial is to learn if topical netarsudil/latanoprost works to treat pseudophakic bullous keratopathy in patients with glaucoma. The main questions it aims to answer are: Does topical netarsudil/latanoprost improves visual function in patients with glaucoma and pseudophakic bullous keratopathy? Does topical netarsudil/latanoprost affects the central corneal thickness (CCT) in patients with glaucoma and pseudophakic bullous keratopathy? Researchers will compare topical netarsudil/latanoprost to a placebo (a look-alike substance that contains no drug) to see if topical netarsudil/latanoprost works to treat pseudophakic bullous keratopathy (PBK). Participants will take topical netarsudil/latanoprost or a placebo every day for 12 weeks and visit the clinic once every two weeks for checkups and tests.

Detailed description

Patients with glaucoma and pseudophakic bullous keratopathy will be randomly divided in two groups. Group 1 will take topical netarsudil/latanoprost 1x daily for 3 months and group 2 will take topical placebo (artificial tear substitute) 1x daily for 3 months. Visual acuity (VA) will be evaluated using Snellen chart and converted to logarithm of the minimum angle of resolution (LogMAR). Central corneal thickness (CCT) measurements will be performed using OCT (Optovue Ivue). Information about intraocular pressure and adverse effects will be recorded during the study. Patients will visit every two weeks for checkups and measurements for 12 weeks.

Interventions

DRUGNetarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution

Patients with pseudophakic bullous keratopthy and glaucoma will receive topical netarsudil/latanoprost 1x daily for 12 weeks.

DRUGPlacebo

Patients with pseudophakic bullous keratopathy and glaucoma will receive topical placebo 8artificial tear substitute) 1x daily for 12 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

40 Years to 90 Years

Healthy volunteers

Inclusion criteria

* both sex, * age between 40 and 90 years * pseudophakic bullous keratopathy * glaucoma

Exclusion criteria

* other anterior segment pathology (corneal opacities); * ocular surface inflammation * retinal diseases affecting visual acuity * current treatment with topical prostaglandin analogue

Design outcomes

Primary

Measure	Time frame	Description
Visual acuity (VA)	12 weeks	Visual acuity measurements using Snellen chart and converted to logMAR

Secondary

Measure	Time frame	Description
Central corneal thickness (CCT)	12 weeks	CCT will be measured using OCT (Optovue iVue)

Countries

Croatia

Contacts

STUDY_DIRECTORJosip Pavan, MD, PhD

University Hospital Dubrava

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 10, 2026