Replication Study: Reducing Pain With Focused Music Listening

Healthy Volunteers, Pain, Painful, Pain Intensity, Pain Intervention, Pain Management, Pain Threshold, Psychomotor Performance

Pain, Pain Perception, Experimental Pain, Analgesia, Music, Music Listening, Sensorimotor Synchronization, Tapping, Rhythm, Electrical Pain Stimulation, Replication Study, Endogenous Opioid System, Attention, Emotion, Affect, Pain Management, Music Therapy

The goal of this clinical trial is to confirm previous findings that actively tapping along to music can reduce pain more than just listening to music. This study aims to replicate the findings of a previous study (NCT05267795), with one change in how mild pain is created for the experiment. This study involves healthy adults. The main questions the study aims to answer are: 1. Does actively tapping along to music lower feelings of pain compared to just listening to music? 2. Does actively tapping along to music lower feelings of pain compared to being in silence (with or without tapping)? 3. Is this method of using music and tapping helpful for managing pain? Researchers will compare the amount of pain participants feel in four different situations: 1. Listening to music while actively tapping their foot along with it. 2. Just listening to music while resting their foot. 3. Actively tapping their foot in silence. 4. Sitting in silence while resting their foot. Participants in this study will: Experience brief moments of mild pain on their forearm. This pain is safely created using a small electrical pulse from a device held gently on the skin by the researcher. (This replaces the pressure method used in the original study). Sometimes listen to music through headphones, and sometimes sit in silence. Sometimes tap their foot along to the music or a beat, and sometimes rest their foot. Rate how much pain they feel on a number scale after each pain pulse. Answer short questions about their mood during the experiment. Answer questions about how familiar they are with the music and how much they liked it at the end.

This study is a pre-registered replication of a previous trial (NCT05267795) investigating the analgesic effects of sensorimotor synchronization to music. While music listening alone has shown small, albeit reliable, pain-reducing effects, recent theories propose that active synchronization (like tapping or dancing) engages the endogenous opioid system (EOS), potentially leading to stronger analgesia and enhanced social bonding. The original study provided initial evidence supporting this, finding that actively tapping to music significantly reduced experimentally induced pain compared to passive music listening or silence conditions. This replication study aims to confirm the primary finding that sensorimotor synchronization to music significantly reduces pain perception compared to passive music listening and control conditions. The study employs a 2x2 within-subjects factorial design with two factors: Auditory Condition (Music vs. Silence) and Task Condition (Active Tapping vs. Passive Control). Healthy adult participants will undergo all four conditions. The primary methodological difference from the original study is the method of pain induction. Instead of pressure algometry, this study will use non-invasive transcutaneous electrical stimulation applied to the participant's forearm via a BIOPAC HSTM01 certified stimulus device. This change was implemented to allow for potentially greater precision and control over the stimulus intensity compared to manual pressure application. Pain intensity will be individually calibrated for each participant based on their pain threshold, ensuring only mild to moderate pain levels are experienced. Safety protocols, including screening for contraindications (e.g., pacemakers, epilepsy, pregnancy, local malignancies) and continuous monitoring, are in place. Consistent with the original study, perceived pain intensity will be the primary outcome measure, rated on a numerical scale after each stimulus. Secondary measures, including ratings of emotional state (pleasantness, arousal), music familiarity, and music preference, will be collected to explore potential attentional and emotional mechanisms underlying the observed effects, as suggested by the original research. This replication seeks to provide robust evidence regarding the potential for active musical engagement, specifically sensorimotor synchronization, as a tool for pain management.

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