Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Non-Cardiac Surgery Patients

Association Between Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Patients Undergoing Non-Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06959446

Enrollment

29156

Registered

2025-05-06

Start date

2014-01-01

Completion date

2023-12-31

Last updated

2026-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AKI - Acute Kidney Injury, Elderly, Homocysteinemia, Mortality, Postoperative

Brief summary

This study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy levels may reflect metabolic shifts, highlighting their potential value in predicting adverse postoperative outcomes. These findings suggest that monitoring perioperative Hcy levels and their changes could help identify high-risk patients and inform postoperative management strategies.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

•Hospitalized older (≥ 65 years) patients underwent non-cardiac surgery

Exclusion criteria

* Without preoperative Hcy data (n= 44115) * Neurosurgery (n= 3343) * Kidney or renal artery surgery (n= 2478) * Chronic kidney disease (n=577)

Design outcomes

Primary

Measure	Time frame
Acute kidney injury (AKI)	January 2014 - December 2023

Secondary

Measure	Time frame
mortality	January 2014 - December 2023

Outcome results