Hip Fracture of Intertrochanteric Type, Osteopenia, Thromboembolic Event, Thrombosis Embolism
Conditions
Keywords
hip fracture, serpinh1, thromboembolism, rock1
Brief summary
Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively mobile patients due to advanced immobility before the fracture, and whether they participants have a similar risk of VTE to the normal population despite having had a hip fracture and surgery.
Detailed description
In this study, the investigators aimed to prospectively measure the Hsp 47 gene expression levels in patients scheduled for surgery due to intertrochanteric femur fracture and healthy volunteers in the same age group and compare the results with the literature. Also the complications prior or after surgery will be compared.
Interventions
GENETICGene Expression Analysis
Each subject analysed for SERPİNH1 and ROCK1 gene exppression
Sponsors
Saglik Bilimleri Universitesi
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
All patients undergo genetic expression analysis of HSP 47 (SERPİNH1, ROCK1) and the also classified by their mobility score before fracture. There is also a control group consist of age appropied healty adults
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* \>65 years of age * Interthrocanteric femur fracture AO Type 31A1, 31A2, 31A3 * Patients treated proksimal femoral nail * Minor trauma * Fracture mobility score 1,2,3,4,5 * Inial thrombocytes count 150.000-450.000 /µL
Exclusion criteria
* Body mass index \>40 * Fracture mobility score 6 (unknown type) * stage 4 chronic kidney disease * Patients with rheumatological diseases * Patients at serious risk of VTE(Venous thromboembolism) (according to the International Society on Thrombosis and Hemostasis, categorization of venous thromboembolism) : * Active Hematologic Cancer * Antiphospholipid syndrome * History of recurrent thrombosis (DVT) * Paroxysmal nocturnal hemoglobinuria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HSP 47 | Gene expression analysis will be performed once samples are collected from all participants. | HSP 47 (SERPİNH1, ROCK1) gene expression analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thromboembolie | from fracture occur up to one year | Thromboembolic events |
Countries
Turkey (Türkiye)
Outcome results
None listed