Colorectal Cancer Stage II, Colorectal Cancer Stage III, T4 Colorectal Cancer
Conditions
Brief summary
The outcome of T4 locally advanced colon cancer is poor when locoregional recurrence occurred. Previous studies had showed that the aggravation of T4 colon cancer is higher than N-positive colon cancer, contributing to staging paradox that outcomes of stage IIB/C are poorer than stage IIIA colon cancer and higher locoregional recurrence of stage IIB/C colon cancer. The phenomenon cannot be explained by radicality, lymph node harvested and adjuvant chemotherapy administration. To elucidate the cancerous aggravation of T4 colon cancer, the investigators should dive into the clinicopathology, metastatic mechanism and cancer biology. The investigators hypothesize that peritoneal spreading can be one of the metastatic routes of T4 colon cancer; however, few studies have addressed the finding and deserved investigation. Previous research have found that serum epigenetic alterations and cell-free DNA can serve as a prognostic marker for stage II/III colon cancer. Therefore, the aim of this study is (1) to explore the role of ascites cfDNA as a potential biomolecular marker for locoregional recurrence; (2) to identify the risk factors of locoregional recurrence for T4 colon cancer by correlating biomolecular markers between clinicopathology, epigenomic alterations in blood and ascites.
Interventions
PROCEDURERadical surgery for colon and rectum cancer
Radical surgery for colon and rectum cancer indicates that the surgery intends to eradicate all identifiable tumor in the human body.
PROCEDURERadical surgery for colorectal cancer
Radical surgery for colorectal cancer indicates that the surgery intends to eradicate all identifiable tumor in the human body.
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Inclusion Criteria: 1. Age ≥ 18 years old 2. Diagnosed as colorectal cancer 3. Undergo radical colectomy or palliative colectomy, not limited to minimally invasive surgery or open surgery *
Exclusion criteria
1. Age\<18 years old 2. Pregnancy 3. Patients with peritoneal dialysis 4. Patients who are unwilling to undergo colorectal surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation the cell-free DNA level and sequencing between ascites and serum | One year |
Countries
Taiwan
Contacts
Primary ContactYu-Tso Liao, MD, PhD
Outcome results
None listed