ARDS (Moderate or Severe)
Conditions
Keywords
Chest ultrasound, electrical impedance tomography
Brief summary
1. To evaluate the dynamic changes of lung ultrasound during electrical impedance tomography (EIT) PEEP titration and across the first week of ARDS. 2. To asses respiratory effort by diaphragmatic function, esophageal pressure, and EIT (Pendelluft phenomenon), and hyperinflammatory biomarkers, to predict P-SILI. 3. To develop predictive models for weaning success based on integrated EELI and thoracic ultrasound.
Interventions
DIAGNOSTIC_TESTElectrical impedance tomography
* Electrical impedance tomography (EIT)：Assessing pulmonary function in chronic lung diseases. * Lung ultrasound：Assessing diaphragm atrophy in mechanically ventilated patients. * Esophageal pressure：The work of breathing, or the energy required by respiratory muscles to meet ventilatory demands, can be directly evaluated by esophageal pressure * Oxygen consumption：Indirectly evaluated by measuring oxygen consumption (V̇O2) during mechanical ventilation The oxygen cost of breathing, reflected the increase in V̇O2 when transitioning from mechanical ventilation to spontaneous breathing, has been shown to predict weaning outcomes.
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult \>18 y/o. * Patient intubated and receiving mechanical ventilation \> 24 hours. * Admitted into ICU, diagnosed as moderate or severe ARDS (ICD-10-CM: J80) according to Berlin definition.
Exclusion criteria
* Presence of Implanted Electronic Devices (pacemakers, implantable cardioverter-defibrillators). * Pregnancy. * No consent/inability to obtain consent and appropriate legal representative not available.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ARDS | From enrollment to the end of treatment at 1 weeks. | Correlation of LUS aeration scores and overdistension metrics (e.g., A-line prominence, reduced lung sliding) with EIT parameters, including hyperdistension (%), collapse (%), and ΔEELI. Correlation of P-SILI risk with diaphragmatic function (ultrasound-measured excursion and thickening fraction), esophageal pressure variations (ΔPes, ΔPdi), pendelluft dynamics (phase shift, amplitude difference from EIT), and hyperinflammatory biomarkers (e.g., IL-6, IL-8). |
Contacts
Primary ContactYao-Wen Kuo
Outcome results
None listed