Cancer, Cardiovascular Diseases (CVD), Comorbidity, Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes), Inter- and Transgenerational Inheritance, Offspring, Adult, Prevention
Conditions
Brief summary
This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. Based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. General demographic information will be collected, and anthropometric measurements will be refined. A structured questionnaire will be used to gather disease history, family history of diabetes, and related information. Comprehensive diabetes-related laboratory screening and complication assessments will be conducted. A standardized biobank will be established, including blood and urine samples from the Da Qing Offspring Study, to support future research on epigenetics, metabolomics, and other mechanisms.
Interventions
BEHAVIORALLifestyle interventions
Dietary intervention: 30kcal energy intake per kilogram of body weight per day, increase vegetable intake, control sugar and alcohol intake, encourage overweight and obese people to lose weight, lose 0.5-1kg per month until the weight reaches the target. Exercise intervention: Appropriate physical activity in spare time, 30-40 minutes per day, 5 times a week.
Sponsors
Daqing Oil Field Hospital
China-Japan Friendship Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Spouses of the original Daqing diabetes Prevention Research Population (IGT), offspring 1 to 3 generations, and offspring spouses were included in the study, without special restrictions on subjects' gender, age, basic disease status, etc。 * Conduct a death agent investigation for some deceased members.
Exclusion criteria
▪People who are unwilling to participate in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative incidence rate of diabetes | Through study completion, an average of about 1.5 years | This study statistically analyzed the cumulative incidence rate of diabetes at the end of the study through interview, medical record review, physical examination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| weight | Through study completion, an average of about 1.5 years | The subject's weight is recorded and the results are reported in kilograms. |
| waist circumference | Through study completion, an average of about 1.5 years | The subjects' waist circumference was recorded and the waist circumference results were reported in centimeters. |
| Height | Through study completion, an average of about 1.5 years | The subject's height was recorded, and the results were recorded in centimeters. |
| Exercise frequency and intensity | Through study completion, an average of about 1.5 years | The subjects' daily exercise frequency and intensity were recorded. |
| Coronary heart disease incidence | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of coronary heart disease at the end of the study through interview, medical record review, physical examination |
| all-cause deaths | Through study completion, an average of about 1.5 years | This study counted all-cause deaths at the end of the study through death certificate, medical record review, family interview |
| incidence of diabetic peripheral neuropathy | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of diabetic peripheral neuropathy at the end of the study through interview, medical record review, physical examination |
| other cause mortality | Through study completion, an average of about 1.5 years | This study statistically analyzed other cause mortality at the end of the study through death record, medical record review, family interview |
| incidence of blindness | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of blindness at the end of the study through interview, medical record review, physical examination |
| Diabetic retinopathy incidence | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of diabetic retinopathy at the end of the study through interview, medical record review, physical examination |
| Diabetic nephropathy incidence | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of diabetic nephropathy at the end of the study through interview, medical record review, physical examination |
| Peripheral vascular disease incidence | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of peripheral vascular disease at the end of the study through interview, medical record review, physical examination |
| cardiovascular mortality rate | Through study completion, an average of about 1.5 years | This study statistically analyzed the cardiovascular mortality rate at the end of the study through death certificate, medical record review, family interview |
| Stroke incidence | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of stroke at the end of the study through interview, medical record review, physical examination |
| dietary habits | Through study completion, an average of about 1.5 years | The subjects' eating habits and dietary preferences were assessed through patient interviews. |
| health-related quality of life | Through study completion, an average of about 1.5 years | The EuroQol questionnaire or health status questionnaire was administered through patient interviews to assess the subjects' health-related quality of life. |
| blood pressure | Through study completion, an average of about 1.5 years | During the visit, the subjects' systolic and diastolic blood pressures were measured at rest by physical examination. The measurements were performed twice and the average was taken. |
| blood sugar | Through study completion, an average of about 1.5 years | Blood samples were collected from the subjects at 1 hour and 2 hours after the steamed bread meal when they were fasting. The blood samples were used to test blood sugar levels and blood lipids, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. |
| blood lipid | Through study completion, an average of about 1.5 years | Venous blood was collected from the subjects in a fasting state. The blood samples were used to test blood lipid status, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. |
| skin AGE | Through study completion, an average of about 1.5 years | The skin AGE of the subjects was measured by physical examination. After cleaning the inner skin of the forearm, the AGE Reader probe was gently placed on the skin surface, the excitation light was emitted and the fluorescence intensity was recorded. The results were repeated 3 times and the average value was taken. |
| Tidal Volume | Through study completion, an average of about 1.5 years | The subjects were assessed for Tidal Volume, which reflects the ventilation efficiency in the basic breathing state. Tidal Volume is measured in liters. |
| Functional Residual Capacity | Through study completion, an average of about 1.5 years | Subjects were assessed for Functional Residual Capacity, which reflects lung capacity. Functional Residual Capacity is measured in liters. |
| Forced Vital Capacity | Through study completion, an average of about 1.5 years | The subjects were assessed for Forced Vital Capacity, which reflects the overall ventilation capacity of the lungs. Forced Vital Capacity is measured in liters. |
| Forced Expiratory Volume in 1 second | Through study completion, an average of about 1.5 years | The subjects were assessed for Forced Expiratory Volume in 1 second, which reflects respiratory reserve capacity. Forced Expiratory Volume in 1 second is measured in liters. |
| Heart failure incidence | Through study completion, an average of about 1.5 years | This study statistically analyzed the incidence of heart failure at the end of the study through interview, medical record review, physical examination |
Countries
China
Outcome results
None listed