Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06958354

Enrollment

1529

Registered

2025-05-06

Start date

2023-03-15

Completion date

2025-10-19

Last updated

2025-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacteremia and Sepsis, Intensive Care Medicine, Procalcitonin, Sepsis, Septic

Keywords

procalcitonin, sepsis, septic shock, intrensive care medicine

Brief summary

In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality. Early recognition of sepsis and appropriate antibiotic use for the causative agent is one of the most important steps in the fight against sepsis. Procalcitonin (PCT) is a calcitonin precursor peptide and has been reported to predict bacteremia early. While the PCT concentration level is negligible in healthy individuals, it has been shown to increase especially in bacterial infections, sepsis, trauma and burns. In our study, our aim is to determine whether there is a relationship between serum PCT concentration levels taken within 24 hours according to the time of the sample taken for blood culture with growth in patients followed up in our Internal Intensive Care Unit.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Positive blood culture during their follow up * Patients over 18 years of age

Exclusion criteria

* Those under the age of 18 * Those who have had surgery or trauma in the last 72 hours * Those with a history of autoimmune disease, chronic renal failure * Patients admitted to intensive care due to acute pancreatitis, pregnancy, burns. * Patients with incomplete data.

Design outcomes

Primary

Measure	Time frame
Correlation of serum PCT levels measured within 24 hours of culture in intensive care patients with bacteremia and the pathogen type (Gram-positive, Gram-negative, fungal) in the culture result.	In patients with positive blood cultures, serum PCT values studied within the first 24 hours from the time the culture sample was taken will be evaluated retrospectively.

Secondary

Measure	Time frame
Diagnostic power of PCT levels in distinguishing Gram-negative, Gram-positive and fungal infections	serum PCT values studied within the first 24 hours from the time the culture sample

Countries

Turkey (Türkiye)

Outcome results