Diabetic Neuropathy, Sarcopenia
Conditions
Keywords
diabetic neuropathy, muscle mass, sarcopenia, nerve conduction studies
Brief summary
The goal of this observational study is to evaluate the relation between diabetic neuropathy in type 2 diabetes mellitus patients and muscle mass
Detailed description
The goal of this observational study is to evaluate the relation between diabetic neuropathy in type 2 diabetes mellitus patients, aged above 45 years old, and muscle mass; where it uses ultrasound to measure anterior thigh muscle thickness and adjusts it to body mass index to calculate muscle mass and the participants perform clinical tests i.e hand grip strength test and chair stand test in order to assess muscle power. Depending on both muscle mass and muscle power/function, Sarcopenia could be assessed in this group of patients, and its relation to diabetic neuropathy, tested by nerve conduction studies, would be researched.
Interventions
None listed
Sponsors
Ain Shams University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The study group consisted of patients diagnosed with Type 2 diabetes mellitus aged ≥45 years old
Exclusion criteria
* Type 1 DM, gestational diabetes mellitus * Severe cardiopulmonary disease, significant/previous neurological disorder (e.g., ischemic stroke, Parkinson disease) causing difficulty during daily activities (e.g., walking), visual deficit, and psychiatric problem * Other neuropathy-associated factors such as: alcohol, nutrition, poisoning and drug addiction * Patients with renal diseases, malignancy and autoimmune diseases * Patients on long term use of Steroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relation between diabetic neuropathy and muscle mass | Day 1 Neurological examination and clinical physical performance tests for sarcopenia, 2 weeks later: nerve conduction studies for both lower limbs, the 3rd week: ultrasound assessment for thigh muscle thickness | Relation between Diabetic neuropathy severity (mild/moderate/severe) using nerve conduction studies classification criteria (Baba's classification) and skeletal muscle mass as indicated by a ratio (anterior thigh muscle thickness measured by ultrasound/ BMI) (millimeteres for muscle thickness ) and (kg/m\^2 for the BMI) |
Countries
Egypt
Contacts
Primary ContactWafaa M Mohamed Abd ElAzim, Masters degree
Outcome results
None listed