Intrapartum Antibiotics, Maternal and Neonatal Sepsis
Conditions
Brief summary
In this study, we want to see the role of the antibiotic, azithromycin, in preventing maternal and neonatal infections, if the drug is given intrapartum to the mother
Interventions
we will be administering single-dose oral azithromycin to ladies who go into labor and have no risk factors for sepsis, as there is increased risk of postpartum sepsis in both mother and neonate after normal vaginal delivery in low-income and middle-income countries
OTHERno azithromycin
participants in this arm will be given only standard labor care and no oral azithromycin
Sponsors
Armed Forces Hospital, Pakistan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* pregnant ladies with no risk factors for sepsis who go into spontaneous labor or induced labor
Exclusion criteria
* pregnant with risk factors for sepsis like maternal fever , raised WBC count, chorioamnionitis, or having. history of any adverse even with macrolides
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maternal infections | birth to 6 weeks post partum |
Secondary
| Measure | Time frame |
|---|---|
| neonatal infections | birth to 6 weeks post partum |
Outcome results
None listed