Cardiovascular Health, Sleep
Conditions
Brief summary
The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. The main aims of the project are: * To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals. * To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals. * To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals. Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).
Interventions
30% reduction in habitual time in bed
Sponsors
Florida State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months) OR * Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)
Exclusion criteria
* Chronic, uncontrolled disease (cardiovascular, metabolic) * Poor sleep (regularly achieving \<7 hours of sleep per night) * Musculoskeletal injury in the last 6 months * Obese (grade II or higher) * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial Stiffness (i.e., carotid-femoral pulse wave velocity) | Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep | Carotid-femoral pulse wave velocity measured via applanation tonometry |
| Central Hemodynamics | Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep | Central Blood Pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardio-Autonomic Function | Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep | heart rate variability |
| Cognitive Performance | Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep | impulse control; measured via vetted smart phone application (Sway Medical; Tulsa, OK) |
| Physical Performance | Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep | hand grip strength |
| Inflammation | Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep | CRP |
Countries
United States
Contacts
Primary ContactBrett Cross
Backup ContactMichael Ormsbee
Outcome results
None listed