Acute Appendicitis, Appendicitis Perforated
Conditions
Keywords
Single-center, prospective, cross-sectional
Brief summary
The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation
Detailed description
The study aims to assess hyperbilirubinemia: serum direct, indirect and total bilirubin to enhance the diagnostic accuracy of acute appendicitis. Also it aims to analyze different patient variables such as age, gender, duration of symptoms, leukocyte and neutrophil count, Alvarado score, presence of fever, nausea & vomiting, peritonitis alongside serum total bilirubin level in patients with appendicitis and assess which variables can be taken as independent factors to predict appendiceal perforation.
Interventions
OTHERNon-interventional
Non-interventional study
Sponsors
Nepalese Army Institute of Health Sciences
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
5 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients of age group above 5 years with acute appendicitis undergoing appendectomy with written informed consent.
Exclusion criteria
* Patients with appendicular lump. * Patients with acute and chronic liver diseases like acute hepatitis, hemolytic disease, Gilbert's syndrome, Dubin-Johnson syndrome, alcoholic liver disease. * Acquired or Congenital Biliary Disease. * History of Hepatotoxic drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perforated appendix | Presentation to hospital till perioperative period | Perforated appendicitis was confirmed intraoperatively by the surgeon and at histological analysis of the specimen by the rupture of appendiceal wall to the serosa. Those with gangrenous walls were also taken as perforated. |
Countries
Nepal
Outcome results
None listed