PTSD, PTSD - Post Traumatic Stress Disorder
Conditions
Keywords
PTSD, EMDR, SSRIs, Trauma, Mental Health, Randomized controlled trial, Post-traumatic stress disorder, Eye Movement Desensitization and Reprocessing
Brief summary
This randomized controlled trial aims to compare the efficacy of Eye Movement Desensitization and Reprocessing (EMDR) therapy versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the treatment of Post-Traumatic Stress Disorder (PTSD). Adult patients diagnosed with PTSD will be randomly assigned to receive either EMDR therapy or SSRIs for a period of six weeks. The primary outcome is the rate of remission as measured by validated PTSD symptom severity scales at Week 6. Secondary outcomes include changes in functional impairment and patient-reported quality of life. The study seeks to determine whether EMDR therapy is a non-pharmacological alternative to SSRIs for achieving symptom remission in PTSD.
Interventions
Patients in this arm will receive weekly EMDR sessions for 6 weeks
The patients will receive an SSRI medication daily for 6 weeks. The dose will be titrated by the clinician.
Sponsors
Asad Ullah Jan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Age 18-60 years Clinical diagnosis of Post-Traumatic Stress Disorder (PTSD) Duration of illness ≥ 6 months Able to provide informed consent
Exclusion criteria
Current substance abuse or dependence History of psychotic disorder or bipolar disorder Active suicidal ideation Concurrent psychotherapy or psychiatric medication (except study-assigned SSRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Remission rate at Week 6 | 6 weeks | Each group's proportion of participants achieving remission from PTSD is defined as having a score below 22 on the PTSD Checklist for DSM-5 (PCL-5; range 0-80, where higher scores indicate worse PTSD symptoms), a validated PTSD scale. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in functional impairment score | 6 weeks | Change from baseline to 6 weeks in functional impairment as measured by the World Health Organization Quality of Life-BREF (WHOQOL-BREF; range 26-130, higher scores = better quality of life), a validated quality of life scale. |
Countries
Pakistan
Contacts
PRINCIPAL_INVESTIGATORAsad Ullah Jan, MBBS,FCPS
CMH Nowshera
Outcome results
None listed