Correlation Between Serum Albumin Level and Severity of Hepatic Encephalopathy in Patients With Chronic Liver Disease in Sohag University Hospital

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06953921

Enrollment

100

Registered

2025-05-01

Start date

2025-03-12

Completion date

2025-09-12

Last updated

2025-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic Encephalopathy

Brief summary

assess the correlation between serum albumin levels and the severity of hepatic encephalopathy in patients with chronic liver disease. assess the impact of albumin level on clinical course and outcomes of HE.

Detailed description

sample size calculation will be performed based on anticipated incidence rates of HE and variability in serum albumin levels, aiming for a study population of 100-150 patients to achieve adequate statistical power. \- All patients included in the study will be subjected to : Glasgow Coma Scale (GCS) score. Clinical Assessment: Baseline evaluation of patients to confirm chronic liver disease diagnosis and determine clinical characteristics. History of prior episodes of HE, presence of ascites, variceal bleeding, and other complications of chronic liver disease . Age, gender, etiology of cirrhosis (e.g., viral hepatitis, alcohol), comorbid conditions (e.g., diabetes, hypertension) * Laboratory investigation : Serum albumin level AST ALT Total bilirubin and direct CBC Serum creatinine Proth time and concetntration

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* patients aged \>18 years. * Confirmed chronic liver disease (by imaging , * liver function tests , and clinical history). * Diagnosed with hepatic encephalopathy based on clinical criteria. * Patients able to provide informed consent.

Exclusion criteria

* Patients age less than 18 years old * Acute liver failure. * Chronic renal failure on dialysis. * Pregnant women. * Patients with active malignancy.

Design outcomes

Primary

Measure	Time frame	Description
assess the correlation between serum albumin levels and the severity of hepatic encephalopathy in patients with chronic liver disease.	6 months	assess the impact of albumin level on clinical course and outcomes of HE.

Countries

Egypt

Contacts

Primary ContactKerelos L Sweha, Resident

kerolos_latief_post@med.sohag.edu.eg+201280416877

Backup ContactHamdy S Mohamed, Assist.prof

+201111101934

Outcome results