Metabolic-dysfunction-associated Fatty Liver Disease (MAFLD)
Conditions
Brief summary
A growing number of people are being diagnosed with fatty liver disease, also known as metabolic-dysfunction associated liver disease (MASLD). Fatty liver disease can unknowingly progress to serious liver disease and even permanent scarring (cirrhosis).The purpose of this research is to learn the best way to detect serious liver disease as early as possible in patients with fatty liver disease by measuring the stiffness of the spleen. Secondarily, the study hopes to understand how the stiffness of the spleen relates to the severity of liver disease.
Interventions
DEVICEVibration-controlled transient elastography
Liver and spleen stiffness measurements using vibration-controlled transient elastography
Sponsors
William Jennings Bryan Dorn VA Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Able to consent for participation in a clinical study * Able to read and comprehend English * Evidence of fatty liver disease on previous liver biopsy, imaging or clinical documentation
Exclusion criteria
* Pregnant * Known decompensated cirrhosis or hepatocellular carcinoma * Absence of spleen * Documentation of alcohol use disorder or alcohol use greater than 20g/day for women or greater than 30 g/day for men * Unable to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spleen Stiffness measurement | 1 year | Percent of participants with valid spleen stiffness measurements using vibration controlled transient elastography |
Countries
United States
Outcome results
None listed