COVID-19, Inflammatory Response, Pericardial Disease
Conditions
Brief summary
This prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and COVID-19 seropositivity in adult patients undergoing first-time isolated coronary artery bypass grafting (CABG). Pericardial tissue samples were collected during surgery and evaluated histopathologically, while preoperative COVID-19 serological testing was performed. The primary outcome is to determine whether COVID-19 seropositivity is associated with the severity of pericardial inflammation. Patients with prior cardiac surgery, active COVID-19 infection, systemic inflammatory diseases, chronic immunosuppressive therapy, or malignancy were excluded from the study.
Interventions
None listed
Sponsors
Samsun University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Inclusion criteria
* Age ≥20 years * Undergoing first-time isolated coronary artery bypass grafting (CABG) * Availability of pericardial tissue sample for histopathological analysis * Preoperative COVID-19 serological testing performed * Written informed consent obtained
Exclusion criteria
* Previous history of cardiac surgery (e.g., prior CABG, valve surgery) * Concomitant cardiac procedures during the same operation (e.g., valve repair, aortic surgery) * Active COVID-19 infection at the time of surgery (positive PCR test) * Known autoimmune or systemic inflammatory diseases (e.g., lupus, rheumatoid arthritis) * Chronic immunosuppressive therapy (e.g., steroids, biologics) * Known malignancy at the time of surgery Insufficient or inadequate pericardial tissue sample for histopathological assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pericardial inflammation histopatalogical evaluation | up to 1 year | prospective evaluation of the relationship between pericardial inflammation grade (0: absent, 1: mild, 2: moderate, 3: severe) and COVID-19 seropositivity in adult patients undergoing first-time coronary artery bypass grafting. The primary outcome of this study is to investigate the association between pericardial inflammation grade, as determined by histopathological evaluation (categorized as acute, chronic, or absent inflammation), and COVID-19 seropositivity in adult patients undergoing first-time coronary artery bypass grafting. |
Countries
Turkey (Türkiye)
Outcome results
None listed