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The Effect of Molar Incisor Hypomineralisation on the Stomatognathic System

The Effect of Molar Incisor Hypomineralisation on the Stomatognathic System in Children: A Prospective Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06951139
Enrollment
84
Registered
2025-04-30
Start date
2025-03-10
Completion date
2025-03-20
Last updated
2025-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Molar Incisor Hypomineralization

Keywords

elasticity, temporomandibular disorders, ultrasound, masticatory muscle

Brief summary

This study aims to examine whether children with Molar Incisor Hypomineralization (MIH) are more likely to have problems with the jaw joint and chewing muscles. MIH is a dental condition where the enamel of the first molars and incisors is weaker than normal. The researchers performed clinical examinations and ultrasound imaging to evaluate the thickness and elasticity of the chewing muscles. They also used a questionnaire to check for symptoms of temporomandibular disorders (TMD), such as jaw pain, headaches, and joint sounds.

Detailed description

This prospective clinical study investigates the potential impact of Molar Incisor Hypomineralization (MIH) on the stomatognathic system in children. MIH is a developmental enamel defect that affects the first permanent molars and incisors, resulting in weakened enamel and increased sensitivity. While MIH has been well documented in the context of dental health, its broader functional consequences remain underexplored. A total of 84 children aged 9-14 years participated in this study, including 43 with MIH and 41 healthy controls. The evaluation involved both clinical and ultrasonographic examinations. Temporomandibular disorders (TMD) were assessed using the Fonseca Anamnestic Index and through clinical parameters such as joint sounds, headaches, mandibular deviation/deflection, and mouth opening limitation. Ultrasound imaging, including shear wave elastography, was used to evaluate the thickness and elasticity of the masseter, temporalis, and sternocleidomastoid muscles, as well as the articular disc of the temporomandibular joint.

Interventions

DIAGNOSTIC_TESTUltrasound and Shear Wave Elastography

Non-invasive diagnostic imaging techniques used to assess the stomatognathic system. Ultrasound was performed to measure the thickness of the masseter, temporalis, and sternocleidomastoid muscles, as well as the articular disc of the temporomandibular joint. Shear Wave Elastography was used to evaluate the elasticity (stiffness) of the same muscles and joint structures in kilopascals. All evaluations were conducted at rest, using standardized positioning, and by the same experienced operator.

Sponsors

Ozge Gungor
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
9 Years to 14 Years
Healthy volunteers
Yes

Inclusion criteria

* Children aged between 9 and 14 years * Good general health with no systemic disease * Score of 3 or 4 on the Frankl Behavior Rating Scale * No parafunctional oral habits (e.g., bruxism) * No skeletal orthodontic abnormalities * For the MIH group: presence of at least one first permanent molar diagnosed with MIH * For the control group: absence of MIH diagnosis

Exclusion criteria

* Presence of advanced periodontal disease or tooth mobility * History of facial trauma or jaw fracture * Current medication use * Inability to cooperate during clinical or ultrasonographic examinations * Any condition that may affect temporomandibular joint structure or function

Design outcomes

Primary

MeasureTime frameDescription
Prevalence of temporomandibular disorders (TMD) in children with MIHAt the time of enrollment (single clinical visit)The presence of TMD was assessed in both the MIH and control groups using the Fonseca Anamnestic Index and clinical examination. TMD diagnosis was based on signs such as joint sounds, deviation/deflection, headaches, and mouth opening limitation.
Thickness of masticatory muscles in children with and without MIHAt the time of enrollment (single clinical visit)Ultrasound and shear wave elastography were used to evaluate the thickness (in millimeters) of the masseter, temporalis, and sternocleidomastoid muscles bilaterally in both groups. Mean values were calculated and compared.
Elasticity of masticatory muscles in children with and without MIHAt the time of enrollment (single clinical visit)Ultrasound and shear wave elastography were used to evaluate the elasticity (in kilopascals) of the masseter, temporalis, and sternocleidomastoid muscles bilaterally in both groups. Mean values were calculated and compared.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026