Infertility Assisted Reproductive Technology, Oocyte Retrieval
Conditions
Brief summary
This is a monocentric retrospective observational study. The study focuses on the women who underwent Assisted Reproductive Technology (ART) cycles with poor ovarian response (POR), defined as \<4 oocytes retrieved. The objectives of the study are as follows: * Evaluate clinical pregnancy rate (CPR) and cumulative live birth rate (CLBR) in women with poor ovarian response. * Evaluate abortion rate in women with poor ovarian response. * Evaluate the influence of patient characteristics (age, Anti-Müllerian hormone \[AMH\] levels, Antral Follicle Count \[AFC\], Follicle Stimulating Hormone \[FSH\], Body Mass Index \[BMI\]) on women with poor ovarian response. To address the study objectives, data will be collected using a specific internal web-based database. All oocyte retrieval procedures performed at the Humanitas Fertility Center from January 2010 to December 2023 will be included in the evaluation. Outcomes will be expressed in terms of CLBR, CPR and Abortion Rate.
Interventions
PROCEDUREOocyte Retrieval
Oocyte retrieval is performed at the end of ovarian stimulation (OS) to collect oocytes for use in IVF or ICSI cycles.
Sponsors
Istituto Clinico Humanitas
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* The study database will include all women who underwent IVF treatment between 2010 and 2023 and were classified as poor ovarian responders, defined as those who retrieved fewer than 4 oocytes following controlled ovarian stimulation.
Exclusion criteria
* The study database will exclude women who underwent IVF treatment and retrieved more than 3 oocytes following controlled ovarian stimulation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Pregnancy Rate (CPR) | January 2010 - December 2023 | This study aims to evaluate the ART outcomes in women classified as poor ovarian responders (POR), focusing on clinical pregnancy rate. The CPR is defined as the number of clinical pregnancies expressed per 100 initiated cycles. |
| Cumulative Live Birth Rate (CLBR) | January 2010 - December 2023 | This study aims to evaluate the ART outcomes in women classified as poor ovarian responders (POR), focusing on cumulative live birth rates The CLBR is defined as the likelihood of achieving at least one live birth over a series of treatment cycles, including both fresh and frozen embryo transfers, originating from a single ovarian stimulation. |
| Abortion Rate | January 2010 - December 2023 | This study aims to evaluate the ART outcomes in women classified as poor ovarian responders (POR), focusing on abortion rates. Abortion rate is defined as the presence of an empty gestational sac or a gestational sac containing an embryo or fetus without fetal cardiac activity, occurring within the first 12 6/7 weeks of gestation. |
Outcome results
None listed