Ductus Arteriosus, Preterm
Conditions
Keywords
preterm, patent ductus arteriosus
Brief summary
The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus quickly closes itself. The persistent presence of ductus arteriosus leads to significant pressure changes in the systemic and pulmonary circulation, which have adverse effects on extremely/very premature infants. Therefore, persistent patent ductus arteriosus (PDA) is a systemic disease.
Detailed description
hemodynamic significant PDA(hsPDA) is a risk factor for intraventricular hemorrhage(IVH), bronchopulmonary dysplasia(BPD), necrotizing enterocolitis(NEC). A meta-analysis from Cochrane shows that compared to conservative treatment, drug therapy for PDA within 3 and 7 days after birth does not promote PDA closure and reduce the incidence of BPD. Therefore, there is currently a tendency not to provide medication intervention. Although ductus arteriosus quickly closes itself after birth in normal term infants, however, the dynamic changes detail of ductus arteriosus in preterm infants are unknown.
Interventions
OTHERobservation group
in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS)
OTHERcontrol group
in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS)
Sponsors
Chongqing Medical Center for Women and Children
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 1 Hours
Healthy volunteers
No
Inclusion criteria
* less than 32 weeks' gestational age * admission with 1 hours after birth
Exclusion criteria
* congenital abnormalities * parents' refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of patent ductus arteriosus(PDA) | three months after birth | when did the ductus arteriosus close |
| dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow | after admission, 12 hour, 24 hour, 48 hour, 72 hour, 96 hour, 120 hour, 144 hour, 168 hour, 192 hour, 216 hour, 240 hour and 2 weeks or any time of ductus arteriosus closed | dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow were measured |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| necrotizing enterocolotis(NEC) | 36 weeks' gestational age | whether or not NEC was assessed |
| the incidence of bronchopulmonary dysplasia | 36 weeks' gestational age | whether or not bronchopulmonary dysplasia was assessed in 36 weeks' gestational age |
| the incidence of intraventricular hemorrhage(IVH) | 36 weeks' gestational age | whether or not intraventricular hemorrhage(IVH) was assessed |
Countries
China
Outcome results
None listed