Brain Death and Organ Donation in Tunisian Intensive Care Units

Brain Injury, Coma, Organ Transplants

Organ donation refusal, ICU donor management, Cultural barriers, Hemorrhagic stroke outcome

The goal of this observational study was to identify factors associated with the progression to brain death in critically ill patients with severe brain injuries in Tunisian intensive care units (ICUs). The main questions it aimed to answer were: What medical factors (e.g., type of brain injury, ICU stay duration) increased the likelihood of progressing to brain death in these patients? What patient characteristics (e.g., age, comorbidities) influenced the risk of brain death? What were the reasons behind low organ donation rates in Tunisia, including family refusal and hospital-level barriers? Participants were: Adults with severe coma (Glasgow Coma Scale ≤ 8) requiring mechanical ventilation in Tunisian ICUs. Data were collected as part of routine medical care, including information about medical factors, patient characteristics, and family attitudes towards organ donation, without any additional interventions beyond standard care. The study was conducted from November 2022 to November 2023 across three ICUs: Sahloul, Farhat Hached, and Mohamed Taher Maamouri Hospitals.

Background Brain death (BD) is a legally and medically recognized condition under which organ donation may occur. However, organ donation rates in Tunisia remain low compared to international benchmarks. There is a need to better understand the factors influencing the progression to brain death in ICU patients, as well as the sociocultural and institutional barriers to organ donation in this setting. Objectives This study aimed to: Identify clinical predictors of brain death among critically ill patients with severe brain injuries Explore reasons for organ donation refusal by families Identify hospital-level barriers in the organ donation process Study Design and Setting This was a prospective observational cohort study conducted between November 2022 and November 2023 in three Tunisian intensive care units: Sahloul University Hospital (trauma center) Farhat Hached University Hospital Mohamed Taher Maamouri Hospital Participants Adult patients (≥18 years) admitted with severe coma (Glasgow Coma Scale ≤ 8) requiring mechanical ventilation were included. Patients with terminal illnesses unrelated to brain injury were excluded. Procedures Data Collection Data were prospectively collected using a standardized form developed and validated by experts in intensive care and the Tunisian National Centre for Organ Promotion and Transplantation (CNPTO). The collected variables included: Demographic information (e.g., age, sex) Clinical characteristics (e.g., Glasgow Coma Scale on ICU admission, comorbidities, primary diagnosis) Patient outcomes (e.g., progression to brain death, ICU discharge, or death from other causes) Length of ICU stay Organ donation process variables (e.g., whether families were approached, family consent or refusal, organ procurement, reasons for refusal) Family approaches were conducted by the national transplant coordination team from the CNPTO. No experimental interventions were applied. All procedures were part of standard ICU care.

None listed

Tunisia