Acute on Chronic Liver Failure(ACLF), Cirrhosis, Intensive Care Medicine
Conditions
Keywords
prognosis, cirrhosis, ICU, ACLF
Brief summary
Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients. The following hypotheses will be tested: * Improvement in intensive care and overall prognosis compared with data from the literature prior to 2014 * Improved access to liver transplantation compared with the literature prior to 2014 * Improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.). * Centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to TH.
Interventions
OTHERobservational study
This observational study aims to describe the clinical practices and the outcome of patients admitted in ICU.
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between January 2014 and December 2024.
Exclusion criteria
None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day survival | 28 days |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival | through study completion |
| Survival without liver transplantation | 12 months |
| Proportion of patients listed for liver transplantation | through study completion |
| Phenotype of patients admitted to intensive care | baseline |
| Prognostic performance of general and cirrhosis-specific organ failure scores | baseline |
| Comparison of the characteristics of patients on admission in primary care hospitals and in university hospital. | baseline |
| number of patients receiving LT | through study completion |
Countries
France
Outcome results
None listed