Acute Myocardial Infarction, Cardiogenic Shock, Inotropes, Mild Therapeutic Hypothermia, Vasopressors
Conditions
Brief summary
The study aimed to assess the effects of mild therapeutic hypothermia (MTH) on vasopressors and inotropes in patients with cardiogenic shock (CS) due to acute myocardial infarction (AMI).
Detailed description
Cardiogenic shock (CS) is a condition characterized by a severe lack of blood flow to vital organs caused by primary malfunction of the heart, as described by the European Society of Cardiology (ESC) and the American Heart Association (AHA). Acute myocardial infarction (AMI) is a prevalent etiology of CS, constituting a minimum of 30% of the instances. 50% of CS cases manifest upon hospital admission, whereas the remaining 50% occur after hospital admission.
Interventions
Patients received mild therapeutic hypothermia (MTH) to 33°C for 24-36 h
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age from 50 to 70 years. * Both sexes. * Cardiogenic shock post AMI defined by systolic blood pressure \<90 mm Hg for \>30 minutes or motropes required to maintain a systolic blood pressure \>90 mm Hg in the absence of hypovolemia with signs of pulmonary congestion and signs of impaired organ perfusion defined by at least 1 of the following: altered mental status; cold, clammy skin; urine output \<30 mL/h; or arterial lactate \>2 mmol/L. 2\. Intubated and sedated
Exclusion criteria
1. Self-ventilated 2. Indication for targeted temperature management by current guidelines out of hospital cardiac arrest with return of spontaneous circulation (ROSC)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of stroke | 30 day after the procedure | Incidence of stroke until day 30 was recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Duration of mechanical ventilation | Up to 7 days | Duration of mechanical ventilation was recorded. |
| Length of intensive care unit stay | Up to 2 weeks after the procedure | Length of intensive care unit (ICU) stay refers to the total duration a patient remains in the ICU, beginning from the moment of admission to the ICU until their discharge or transfer to a less intensive care setting, such as a regular hospital ward or home. |
| Duration of inotropic support | Intraoperatively | Duration of inotropic support was recorded. |
| Incidence of mortality | 30 days after the procedure | Incidence of mortality was recorded. |
Countries
Egypt
Outcome results
None listed