Coronary Artery Disease, Microvascular Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction
Conditions
Keywords
AccuIMR, CMR, infarct size
Brief summary
In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR values and cardiac magnetic resonance (CMR) results.
Interventions
DIAGNOSTIC_TESTCMR
Coronary microvascular function was assessed using contrast-enhanced CMR after PCI.
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* (1) STEMI patients who underwent PCI within 12 hours of symptom onset. * (2) coronary microvascular function was assessed using contrast-enhanced CMR after PCI.
Exclusion criteria
* (1) Suboptimal coronary angiographic images, including inadequate contrast opacification, unsatisfactory projection view, and severe overlap or distortion of the target vessel. * (2) Lacking two angiographic projections separated by at least 25° apart post-PCI. * (3) Inadequate CMR image quality
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CMR | CMR was performed at a median of 5 days post-reperfusion. | Contrast-enhanced CMR was performed on a 3.0-T scanner (Achieva TX, Philips Healthcare, Best, The Netherlands) . All sequences were acquired during breath-hold with a field of view at 350 × 350 mm2. Two experienced readers, blinded to clinical data, evaluated the CMR results using validated software (QMass MR 7.5, Medis, Leiden, The Netherlands). The acquired images were utilized to assess ventricular parameters and calculate the left ventricular ejection fraction (LVEF). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LDL-C, mmol/L | Blood samples were collected after a 12-hour fast in the second day post-PCI. | Low-density cholesterol (LDL-C) is the cholesterol in low-density lipoprotein (LDL), which reflects how much LDL is present. |
| HbA1c, % | Blood samples were collected after a 12-hour fast in the second day post-PCI. | Hemoglobin a1c (HbA1c) is the combination of hemoglobin and blood sugar. Its concentration in the blood is stable and is not affected by short-term blood sugar concentrations. Hemoglobin A1C has obvious clinical value in the diagnosis of diabetes. |
Countries
China
Outcome results
None listed