Skip to content

Frequency of Food Allergy Confirm by Oral Food Challenge Among Foods Avoidance in Atopic Dermatitis Children

Validation of Food Allergies in Pediatric Atopic Dermatitis Patients Practicing Food Avoidance

Status
Enrolling by invitation
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06947252
Enrollment
200
Registered
2025-04-27
Start date
2025-01-29
Completion date
2029-06-30
Last updated
2025-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic Dermatitis, Food Allergies

Keywords

Atopic dermatitis, Food allergies, Oral food challenge test

Brief summary

Atopic dermatitis can be caused by several factors, including food allergy. Currently, the diagnosis of food allergy often performing skin tests and measuring specific IgE foods that many studies have shown that about 53% of children with atopic dermatitis have food sensitization, result in avoidance of food intake. But only 15% are confirmed to have a true food allergy, so the purpose of our study is to find the prevalence of food allergy in Thai children with atopic dermatitis who are avoiding some foods, using the oral food challenge to confirm the diagnosis to reduce unnecessary food avoidance and prevent complications from inappropriate dietary restrictions

Detailed description

All subject in this study were patients with history of atopic dermatitis and avoid at least 1 food of egg yolk, egg white, cow milk, peanut, wheat or soy. All of them will undergo a blood testing for specific IgE foods to assess whether they can resume consuming that particular food or they must perform oral food challenge test in hospital to evaluate whether they truly have a food allergy or should continue to avoid that food. The primary outcome was to study frequency of food allergy confirm by oral food challenge among foods avoidance in atopic dermatitis children, focusing on the 6 major food allergens in the Thai children: egg yolk, egg white, cow milk, peanut, wheat and soy. Other outcomes were study type of food reaction after oral food challenge test in atopic dermatitis children (IgE mediated, delayed type: AD flare)

Interventions

DIAGNOSTIC_TESTOral food challenge test

Oral food challenge test at home or in the hospital

Sponsors

Mahidol University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
No minimum to 6 Years
Healthy volunteers
No

Inclusion criteria

* Age ≤ 6 years * Age ≤ 6 years with diagnosis of atopic dermatitis c * Now parent report them avoid at least 1 food of egg yolk, egg white, cow milk, peanut, wheat or soy

Exclusion criteria

* Specific IgE food \> 95%PPV (73-74%PPV in wheat, soy) * Patients with uncontrolled asthma/ atopic dermatitis * Patients who had been treated with some other immunotherapy e.g. SCIT, OIT * Patients with delayed developmental problem or mental disorder * Patient use beta-blocker, ACEI, ARB * Patient who unable to follow up

Design outcomes

Primary

MeasureTime frameDescription
Frequency of food allergy among foods avoidance in atopic dermatitis children7 daysFrequency of food allergy confirm by oral food challenge among foods avoidance in atopic dermatitis children, focusing on the 6 major food allergens in the Thai children: egg yolk, egg white, cow milk, peanut, wheat, soy

Secondary

MeasureTime frameDescription
Type of food reaction after oral food challenge test in atopic dermatitis children7 daysType of food reaction after oral food challenge test in atopic dermatitis children divide to IgE mediated or delayed type (AD flare)

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026