Geriatric, Length of Stay, Malnutrition
Conditions
Keywords
Geriatric, Disease-related malnutrition, Physiology, Acute illness, Deep phenotyping, Nutritional status
Brief summary
Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival. DRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood. This project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.
Interventions
OTHERExposures and measurements
Anthropometry, Body composition (BIA), Nutritional screening (GLIM, SNAQ, NIS, NRS-2002), Functional tests, Seisomocardiography, Muscle strength, Blood tests, Fecal swabs, Indirect calorimetry Orientation-Memory-Concentration (OMC), Sarcopenia, Frailty (Clinical Frailty Scale), Comobidity, Polypharmacy, Portrait photo.
Sponsors
Bispebjerg Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Acutely admitted adults aged 65 years and above. * Be able to comply with the study information, as assessed by the research personnel. * Be able to understand Danish.
Exclusion criteria
* \<24 hours admission * Terminal illness in end stage of life * Patients with temporary civil person registration number (CPR)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Length of Hospital Stay | From date of hospital admission untill discharge, assessed up to 2 months | Time (in hours) hospitalized from arrival to discharge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Readmission | Time to readmission 30 days from discharge | Time to readmission from discharge |
| Acute contact | Time to acute contact 30 days from discharge | Time to acute contact from discharge |
| Mortality | Time to mortality 90 days from index admission | Time to mortality from index admission |
Countries
Denmark
Contacts
Primary ContactJacob B Jespersen, MSc
Outcome results
None listed