Eosinophilic Pulmonary Diseases, Eosinophil Subtype
Conditions
Brief summary
The study subjects of this research are patients with eosinophil-associated pulmonary diseases, including eosinophilic granulomatosis with polyangiitis, idiopathic hypereosinophilic syndrome, idiopathic acute eosinophilic pneumonia, idiopathic chronic eosinophilic pneumonia, and primary simple pulmonary eosinophilia. The aim is to detect eosinophil subtypes in peripheral blood based on surface protein expression, to understand the differences in eosinophil subtypes among patients with different diseases, to elucidate the significance of different eosinophil subtypes, and ultimately to provide a theoretical basis for the selection of treatment directions for patients.
Interventions
OTHERobservation
observation
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* For Healthy Volunteers: healthy volunteers matching the age and gender of the study subjects * For EPD: ① Persistent eosinophil count increase\>1500 per cubic millimeter for more than 6 months. ② Lack of evidence of a secondary cause of eosinophilia is required. ③ Signs and symptoms of end-organ damage presumed to be secondary to eosinophilia
Exclusion criteria
* Patients with concurrent definitive pulmonary infections, malignancies, or other parenchymal lung diseases; * Patients who are unable or unwilling to cooperate with the collection of clinical information (e.g., due to mental disorders, memory impairments, etc.); * Patients who are unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of Eosinophil Subtypes in Serum | From January 1, 2024 to January 1, 2027 | Proportion of Eosinophil Subtypes in Serum Before and After Treatment in Patients |
Countries
China
Contacts
Primary ContactJuhong Shi, M.D
Outcome results
None listed