Sickle Cell Disease
Conditions
Keywords
Sickle Cell Disease, Transfusion, Alloimmunization
Brief summary
The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfusions. This response is called an alloimmune response. We strongly believe that when someone has an alloimmune response, it is caused by changes in their genes. We plan to compare changes in the genes of individuals that develop red blood cell alloimmunization after blood transfusions with those that do not develop alloimmunization. This may help us to create more targeted therapeutic interventions, which may improve the health of alloimmune responders.
Detailed description
Study Description: This study seeks to fine-map risk variants associated with increased susceptibility to developing red blood cell alloantibodies in patients with sickle cell disease (SCD), with the goal of characterizing the molecular basis of the alloimmunization response. This will allow for improved clinical management for individuals susceptible to alloimmunization responses. Objectives: Primary Objective: Elucidate the role of previously identified risk loci in the development of alloantibodies among individuals with SCD. Secondary Objective: Validate and characterize additional, novel alloimmunization-related candidate loci. Endpoints: Primary Endpoint: Completion of analysis of previously identified risk loci to determine the relationship between genome structure and expression. Secondary Endpoint: No additional candidate loci from concurrent discovery studies to evaluate.
Interventions
None listed
Sponsors
National Human Genome Research Institute (NHGRI)
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* INCLUSION CRITERIA To be eligible to participate in this study, an individual must meet all of the following criteria: 1\. Individual (\> 2 years of age) with confirmed SCD diagnosis who meets at least one of the following conditions: 1. History of greater than ten administered transfusions or 20 transfusion units (where known) 2. History of one or more antibody screens 3. Known candidate variant genotype
Exclusion criteria
An individual who meets any the following criteria will be excluded from participation in this study: 1. Impaired decision-making capability, with or without a legally authorized representative 2. History of transplant (e.g., organ, bone marrow, stem cell) 3. Taking immunosuppressive medications at time of enrollment 4. Confirmed pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Completion of analysis of previously identified risk loci to determine the relationship between genome structure and expression. | 5 years | Analyze samples from study participants to determine whether they have the loci we previously identified. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| No additional candidate loci from concurrent discovery studies to evaluate. | 5 years | When we can no longer identify new potentially causal loci, the study endpoint will be achieved. |
Countries
United States
Contacts
CONTACTEmilyn C Banfield
CONTACTNeil A Hanchard, M.D.
PRINCIPAL_INVESTIGATORNeil A Hanchard, M.D.
National Human Genome Research Institute (NHGRI)
Outcome results
None listed