Pediatric Brain Tumor
Conditions
Keywords
Magnetoencephalography, Pediatric Brain Tumor
Brief summary
This observational study aims to evaluate the effectiveness of magnetoencephalography (MEG) in the preoperative assessment of pediatric brain tumors, particularly in determining the extent of resection, and compare it with computed tomography (CT) and magnetic resonance imaging (MRI). The main questions this study aims to answer are: What is the consistency between MEG and CT/MRI in localizing pediatric brain tumors? What is the clinical efficacy of MEG in determining the extent of resection of pediatric brain tumors preoperatively? Participants will: Undergo both MEG and CT/MRI examinations for preoperative assessment, and the extent of tumor resection will be determined by the comprehensive results of the above examinations. Be followed up with MEG and CT/MRI at 1, 3, and 6 months after surgery, along with neurological and quality-of-life assessments.
Interventions
DIAGNOSTIC_TESTMagnetoencephalography plus Computed Tomography/Magnetic Resonance Imaging
Use Magnetoencephalography and Computed Tomography/Magnetic Resonance Imaging in the preoperative assessment of pediatric brain tumors.
Sponsors
Beijing X-Magtech Technology Limited
Guangzhou Women and Children's Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Age range: 3-18 years old; * Clinically diagnosed with brain tumor; * Capable of cooperating with magnetoencephalography evaluation and recording.
Exclusion criteria
* Patients with serious comorbidities or neurological or psychiatric disorders that affect magnetoencephalography examination. * Patients using drugs that affect central nervous system function; * Patients who are not suitable for surgical procedures; * Patients with progressive neurological disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Consistency in Tumor Localization Between Magnetoencephalography (MEG) and Computed Tomography/Magnetic Resonance Imaging (CT/MRI) (Kappa Coefficient) | From enrollment to 12 months after surgery. | The primary outcome will measure the agreement between MEG and CT/MRI (gold standard) in localizing pediatric brain tumors. Consistency will be quantified using the Kappa coefficient (κ), with sensitivity and specificity calculated for MEG against CT/MRI. Data will be aggregated by comparing preoperative MEG localization results (e.g., tumor location categorized by brain regions) with CT/MRI findings. Statistical analysis will include calculation of κ values (95% confidence interval), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) using SPSS version 27.0. |
Countries
China
Contacts
Primary ContactYe Song, Medical Doctor
Outcome results
None listed