Hypertension
Conditions
Keywords
Etiological Classification, Digital Intervention
Brief summary
Eligible participants will first undergo a 1-week home blood pressure diary and 24-hour ambulatory blood pressure assessment. After a confirmed diagnosis of hypertension, etiological subtyping will be performed. Based on the blood pressure evaluation results and etiological classification, the most appropriate antihypertensive medication will be selected. Simultaneously, a personalized lifestyle prescription will be provided according to the patient's individual circumstances. Following medication initiation, participants will continue to monitor their blood pressure through home diaries. Monthly evaluations will be conducted, and if blood pressure fails to reach the target value, medication adjustments will be made based on the blood pressure diary until target levels are achieved. This regimen will be maintained long-term.
Interventions
OTHEREtiological Classification and Digital Intervention
Eligible participants will first undergo a 1-week home blood pressure diary and 24-hour ambulatory blood pressure assessment. After a confirmed diagnosis of hypertension, etiological subtyping will be performed. Based on the blood pressure evaluation results and etiological classification, the most appropriate antihypertensive medication will be selected. Simultaneously, a personalized lifestyle prescription will be provided according to the patient's individual circumstances. Following medication initiation, participants will continue to monitor their blood pressure through home diaries. Monthly evaluations will be conducted, and if blood pressure fails to reach the target value, medication adjustments will be made based on the blood pressure diary until target levels are achieved. This regimen will be maintained long-term.
Sponsors
Shanghai 10th People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-65 years. * Diagnosed primary hypertension (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg). * signed informed consent.
Exclusion criteria
* Secondary hypertension or arrhythmias affecting blood pressure accuracy (e.g., atrial fibrillation). * Comorbidities such as diabetes, chronic kidney disease (eGFR \< 30 mL/min/1.73m²), coronary artery disease, heart failure, or serious valvular heart disease. * History of stroke or myocardial infarction. * Pregnancy, breastfeeding, or planning to become pregnant. * Life expectancy \< 1 year. * Participation in another clinical trial.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Blood Pressure Recorded in a 1-Week Home Blood Pressure Diary | 3 months following intervention | Changes in blood pressure recorded (SBP/DBP) in a 1-week home blood pressure diary from baseline to 3 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in 24-hour Ambulatory Blood Pressure Monitoring | 1/2/3 months following intervention | Change in 24-hour ambulatory blood pressure monitoring (daytime, nighttime, and overall SBP/DBP) at 1/2 /3 months. |
| Change in Home Blood Pressure Monitoring | 1/2 months following intervention | Change in home blood pressure monitoring (SBP/DBP) at 1/2months. |
| Control Rate | 3 months following intervention | Proportion of patients achieving target blood pressure at 3 months. |
| Drug adjustment times | 3 months following intervention | The total number of times to adjust blood pressure medication in 3 months |
Countries
China
Contacts
Primary ContactYi Zhang
Outcome results
None listed