Adults, Botulinum Toxin, Spasticity, Ultrasound
Conditions
Brief summary
This study aimed to compare the safety and outcome of ultrasound (US)- guided botulinum toxin (BoNT) injection and anatomically guided injection in muscle spasticity of different causes in adults.
Detailed description
One of the major complications of neurological diseases is spasticity which is defined as an increased velocity-dependent muscle tone. A large volume of clinical data has demonstrated the efficacy and safety of botulinum toxin type A (BoNT-A) products for treating conditions such as spasticity.
Interventions
DRUGBotulinum toxin injection under anatomical landmark
Patients received botulinum toxin injections under the anatomical landmark.
Patients received ultrasound-guided botulinum toxin injection
Sponsors
Tanta University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years old. * Both sexes. * Patients with muscle spasticity.
Exclusion criteria
\- Patients with contraindications to botulinum toxin injection as allergy, myasthenia gravis, and cerebral palsy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment the range of movement | 6 months after the procedure | The range of movement regarding forearm pronation, thumb flexion, ankle inversion and fingers flexion according to modified Ashworth scale (MAS): score zero indicate no increase in tone, score 1 indicate slight increase in tone, catch or release at end range of motion (ROM), score 1 + indicate a slight increase in tone catch, release, resistance through rest ROM (1/2 ROM), score 2 indicate more marked increase in tone through ROM but affected part moved easily, score 3 indicate a considerable increase in tone, passive movement difficult, score 4 indicate affected part in rigid flexion and extension. It was assessed after three and six months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment the quality of life | 6 months after the procedure | Patients' quality of life (QOL) was assessed before and after intervention with the World Health Organization (WHO)-QOL scale). The WHOQOL is a 26-item instrument consisting of four domains: physical health (7 items), psychological health (6 items), social relationships (3 items), and environmental health (8 items); it also contains QOL and general health items. Each individual item of the WHOQOL-BREF is scored from 1 to 5 on a response scale, which is stipulated as a five-point ordinal scale. The scores are then transformed linearly to a 0-100 scale. |
Countries
Egypt
Outcome results
None listed