Exploring the Links Between Hearing, Cognition and Brain Activity in People With Tinnitus

Exploration Des Liens Entre Audition, Cognition et activité cérébrale Chez Des Personnes présentant un acouphène

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06940726

Acronym

GHOSTTONE

Enrollment

114

Registered

2025-04-23

Start date

2025-05-31

Completion date

2027-11-30

Last updated

2025-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tinnitus

Keywords

tinnitus

Brief summary

The goal of this observational study is to understand the mechanisms underlying tinnitus, and improve the clinical assessment strategies needed to develop targeted therapeutic interventions by comparing endogenous attention capacities in healthy subjects and subjects with tinnitus

Interventions

OTHERQuality of Life questionnaires

Subjects will complete a number of self-questionnaires on subjects such as attention span, anxiety levels and sleep quality.

OTHERHearing tests

listening to sounds on headphones and repeating words

BEHAVIORALAuditory prediction task

listening to sounds and assessing auditory perception

BEHAVIORALAttention task

assessment of reaction time to visual or auditory cues

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age ≥ 18 years * Good written and oral comprehension of the French language * Normal or corrected vision Group of people with tinnitus : \- Chronic tinnitus \> 3 months, uni or bilateral, stable (no period of remission) Control group : \- No tinnitus

Exclusion criteria

* Presence of a known neurological disorder * Presence of a known degenerative pathology * Presence of a known hearing impairment * Presence of a motor disability of the upper limbs * Severe or profound deafness on one or both sides * Person under legal protection (guardianship, curatorship, etc.) * Use of hearing aids

Design outcomes

Primary

Measure	Time frame
Contingent negative variation (CNV) in EEG	2 hours

Secondary

Measure	Time frame	Description
Answer accuracy (% correct answers)	2 hours	Comparison of the variability of the number of correct responses following button presses in behavioural tasks.
Cerebral oscillations (alpha bands) obtained by EEG during behavioural tasks	2 hours	—
Response reaction time (in ms)	2 hours	Comparison of reaction time (RT) variability following response button presses in behavioural tasks
Heart rate variability (in ms)	2 hours	during behavioral task
Pupillometry (pupillary dilation in mm)	2 hours	—
Skin conductance (μS)	2 hours	during behavioral task

Contacts

Primary ContactSéverine Samson

severine.samson@pasteur.fr+33 (0)1 76 53 51 44

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026