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How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?

How Can Prefabricated Membrane-loaded Ascorbic Acid Curtail the Gingival Recession?

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06936592
Acronym
recession
Enrollment
30
Registered
2025-04-20
Start date
2025-04-17
Completion date
2025-10-18
Last updated
2025-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Diseases, Gingival Recession, Localized, Recession, Gingival

Keywords

recession, membrane, ascorbic acide, graft

Brief summary

Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems. Gingival recession can be managed through both non-surgical and surgical interventions The non-surgical approach often involves plaque control and addressing any underlying inflammatory conditions. However, in cases of advanced recession, surgical treatment may be necessary Several treatment techniques have been proposed, which can be divided into pedicle and free grafts. The latter can also be classified as free gingival grafts (FGG) or as connective tissue grafts (CTG). Other treatment options include soft tissue substitutes or regenerative therapies Harvesting graft from the palate has several problems, such as pain, inflammation, bleeding, flap necrosis, and infection at the donor site. For this reason, we need a substitute for soft tissue graft harvesting Carbopol polymers, also known as carbomers, are widely utilized in pharmaceutical formulations for their excellent mucoadhesive properties. This high molecular weight, cross-linked acrylic acid polymers are particularly effective in enhancing the adhesion of formulations to mucosal surfaces, thereby improving drug delivery and bioavailability

Detailed description

Gingival recession is a common finding in daily clinical practice. Several issues may be associated with the apical shift of the gingival margin such as dentine hypersensitivity, root caries, non-carious cervical lesions (NCCLs), and compromised aesthetics. The first step in an effective management and prevention program is to identify susceptibility factors and modifiable conditions associated with gingival recession. Non-surgical treatment options for gingival recession defects include establishing optimal plaque control, removing overhanging subgingival restorations, behavior change interventions, and using desensitizing agents. In cases where a surgical approach is indicated, coronally advanced flap and tunneling procedures combined with a connective tissue graft are considered the most predictable treatment options for single and multiple recession defects. If there is a contraindication for harvesting a connective tissue graft from the palate or the patient wants to avoid a donor site surgery, adjunctive use of acellular dermal matrices, collagen matrices, and/or enamel matrix derivatives can be a valuable treatment alternative. For gingival recession defects associated with NCCLs a combined restorative-surgical approach can provide favourable clinical outcomes. If a patient refuses a surgical intervention or there are other contraindications for an invasive approach, gingival conditions should be maintained with preventive measures. This paper gives a concise review of when and how to treat gingival recession defects.

Interventions

DRUGAscorbic acid

Ascorbic acid induce gingival healing

Sponsors

Minia University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Masking description

participants do not know the type of membrane and the outcomes assessor does not know type of group

Intervention model description

Inclusion criteria: 1. Patients of both genders with ages more than 18 years. 2. At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect. 3. Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I). 4. Non-smoker patients. Exclusion criteria: 1. Pregnant and lactating women. 2. Mal alignment teeth. 3. Patients under active orthodontic therapy. 4. Periodontal therapy during the last 6 months. Groups and intervention: Patients selected in this study will be classified into two groups: • Group 1: Fifteen patients will receive Phase I therapy; reevaluation after four weeks then will be treated with a placebo membrane

Eligibility

Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No

Inclusion criteria

1. Patients of both genders with ages more than 18 years. 2. At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect. 3. Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I). 4. Non-smoker patients.

Exclusion criteria

1. Pregnant and lactating women. 2. Teeth exhibiting pathologic mobility. 3. Mal alignment teeth. 4. Patients under active orthodontic therapy. 5. Periodontal therapy during the last 6 months. 6. Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.

Design outcomes

Primary

MeasureTime frameDescription
Gingival recession heightbaseline, 3months and 6 monthsThe distance from the cementoenamel junction to the gingival margin

Contacts

Primary Contactshaimaa Hamdy, lecturer of Periodontology
shimaa.3m.sh@gmail.com+201030576405

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026