Ultrasound Assessment of Atherosclerotic Plaque Burden and Cardiovascular Risk: A 10-Year Prospective Study

Ultrasound of Carotid and Femoral Plaque Burden and Non-alcoholic Fatty Liver Disease as Predictors of Cardiovascular Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06933745

Acronym

P-SONAR

Enrollment

21029

Registered

2025-04-18

Start date

2022-04-01

Completion date

2025-03-01

Last updated

2025-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atheroscleroses, Atherosclerosis of Femoral Artery, Cardiovascular Diseases, Carotid Artery Plaque, Fatty Liver, Ischemic Cardiovascular Disease, Stroke

Keywords

Ultrasound, Carotid arteries, Femoral arteries, Cardiovascular Disseases, Plaque burden, Subclinical atherosclerosis, NORRISK2, Ischemic stroke, Ischemic heart disease, Atherosclerotic cardiovascular disease

Brief summary

The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance cardiovascular risk prediction beyond NORRISK-2

Detailed description

Design: The P-SONAR Study is a prospective cohort study of all men and women aged 45-74 years attending a health check at one of 10 ultrasound clinics in Norway. Time schedule: Study inclusion and baseline examinations took place in the period April 2022- March 20025. Current status: Ultrasound follow-up examinations take place from January 2025 - December 2029.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 74 Years

Healthy volunteers

Yes

Inclusion criteria

Persons attending a health check during the study period. \-

Exclusion criteria

* If they do not consent to participate

Design outcomes

Primary

Measure	Time frame	Description
Carotid and femoral plaque burden cardiovascular (CV) predictive ability beyond NORRISK-2	From enrollment to an average of 10 years	Additative ability of carotid and femoral plaque burden assessed by ultrasound to predict incident cardiovascular events, beyond conventional risk factors by NORRISK-2
May plaque burden predict incident cardiovascular disease.	From enrollment to an average of 10 years.	Find best cutoff value of wTPT plaque burden to predict incident CV disease, across different age groups and sex.

Countries

Norway

Outcome results