Subarachnoid Hemorrhage, Aneurysmal
Conditions
Brief summary
The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx). The main question it aims to answer is: Whether optimal perfusion pressure is dynamic and changes with time in patients with SAH, and that autoregulation is disrupted in patients during the course of SAH, contributing to delayed cerebral ischemia (DCI).
Interventions
DEVICE- Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)
Near-Infrared Spectroscopy (NIRS) monitors, provided by Edwards Lifesciences, is a monitoring technique. It will be connected to consented patients, automatically capturing brain oxygen as waveform output, and stored in Sickbay system. The NIRS is a non-invasive monitoring method, in which adhesive pads will be applied to forehead. 4 hours continuous monitoring will be recorded on day 1 after SAH (or on presence to NICU), then every three days from day 3 to day 14 (within the DCI window), to 1 to 2 recordings from day 15 to day 21.
Sponsors
University of Alabama at Birmingham
Edwards Lifesciences
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 to 89 years who are admitted to the Neurological Intensive Care Unit (Neuro ICU) between March 2025 and December 2026 for aneurysmal subarachnoid hemorrhage (SAH).
Exclusion criteria
* Patients under 18 years old * Prisoners * Pregnant women * Patients enrolled in concurrent ongoing interventional trial * Students of UAB * Employees of UAB * Patients who undergoes frontal decompression surgery resulting bone flap deficit where NIRS monitoring pads could not be applied.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Lower Limit of Autoregulation (LLA) | 21 days | Successful calculations of moving Lower Limit of Autoregulation (LLA) for all three algorithms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of delayed cerebral ischemia (DCI) to the average LLA | 21 days | Correlation of clinical course of delayed cerebral ischemia (DCI) to average LLA |
| Change in time under LLA | 21 days | Correlation in time under LLA |
| Change in dose under LLA | 21 days | Correlation in dose under LLA |
Countries
United States
Contacts
CONTACTRoxana Santander-Chapeta
CONTACTLaShun L. Horn, M.S.
PRINCIPAL_INVESTIGATORWeifeng Song, M.D., Ph.D
The University of Alabama at Birmingham
Outcome results
None listed