Hypoxic-Ischemic Encephalopathy
Conditions
Brief summary
This study aims to determine if CGM can be safely used in these babies, and to use this alongside innovative methods to measure alternative fuels to optimise care of these vulnerable babies.
Detailed description
In the UK approximately 1200 babies per year undergo 'cooling' for the treatment of 'birth asphyxia' or hypoxic ischaemic encephalopathy (HIE). HIE not only impacts on brain metabolism but disturbs the normal metabolic balance in these babies who are at risk of hypoglycaemia and hyperglycaemia, which may exacerbate the effect of their primary brain injury. The clinical significance of hypoglycaemia is dependent on the availability of alternative fuels such as ketones and lactate. Clinical management of glucose control in these extremely ill babies is challenging because of infrequent blood glucose measurements and inability to measure alternative fuels. We have used continuous glucose monitoring (CGM) to help target glucose control in extremely preterm infants who require intensive care. CGM however has not been used in babies who are being cooled. This study aims to determine if CGM can be safely used in these babies, and to use this alongside innovative methods to measure alternative fuels to optimise care of these vulnerable babies.
Interventions
DEVICECGM
masked continuous glucose monitoring
Sponsors
Kathryn Beardsall
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Days
Healthy volunteers
No
Inclusion criteria
* Hypoxic ischaemic encephalopathy Informed parental consent
Exclusion criteria
* Known significant congenital malformation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percent of time glucose levels measured on CGM are in target | From sensor insertion for up to the first 7 days of life | Percent Time in target (2.6-10mmol/l) |
Countries
United Kingdom
Outcome results
None listed