Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia (GPN)

Efficacy and Safety of the Application of Pulsed Radiofrequency, Combined With Platelet Rich Plasma, to the Treatment of Idiopathic Glossopharyngeal Neuralgia (GPN): A Study Protocol for a Multi-Center, Prospective, Open-Label, Propensity Score Match Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06931457

Enrollment

121

Registered

2025-04-17

Start date

2025-05-01

Completion date

2027-06-01

Last updated

2025-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glossopharyngeal Neuralgia, Platelet Rich Plasma, Pulsed Radiofrequency

Brief summary

To investigate the efficacy and safety of the application of PRF combined PRP to the for the treatment of GPN.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. age \>18 years; 2. diagnosed with idiopathic GPN according to the third International Classification of Headache Disorders (ICHD) classification; 3. patients who failed pharmacotherapy or intolerable side effects of medication; 4. undergoing PRF for GPN; 5. at least 1 month of follow-up recordings.

Exclusion criteria

1. Patients with bilateral GPN; 2. Abnormalities in blood measurements, liver and kidney function, blood glucose, coagulation, electrocardiography or chest radiography; 3. Infection at the puncture site; 4. Previous mental illness; 5. Previous history of narcotic drug abuse; 6. Prior anticoagulant or antiplatelet therapy; 7. An implantable pulse generator; 8. Current pregnancy or breast feeding. 9. Patients with incomplete medical records (lack of baseline data or postoperative follow-up data).

Design outcomes

Primary

Measure	Time frame	Description
Numeric rating scale (NRS) score	1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure	Numeric rating scale (NRS) score during resting was used to evaluate pain intensity before and after PRF treatment (0=no pain, 10=intolerable pain)

Secondary

Measure	Time frame	Description
Barrow Neurological Institute pain scale(BNI score)	1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure	BNI score during resting was used to evaluate pain relief

Countries

China

Contacts

Primary ContactFang Luo, M.D.

13611326978@163.com+86 13611326978

Outcome results